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  EEG biomarkers of activation of the lymphatic drainage system of the brain during sleep and opening of the blood-brain barrier

Semyachkina-Glushkovskaya, O., Karavaev, A., Prokhorov, M., Runnova, A., Borovkova, E., Yu.M., I., Hramkov, A., Kulminskiy, D., Semenova, N., Sergeev, K., Slepnev, A., Yu., S. E., Zhuravlev, M., Fedosov, I., Shirokov, A., Blokhina, I., Dubrovski, A., Terskov, A., Khorovodov, A., Ageev, V., Elovenko, D., Evsukova, A., Adushkina, V., Telnova, V., Postnov, D., Penzel, T., Kurths, J. (2023): EEG biomarkers of activation of the lymphatic drainage system of the brain during sleep and opening of the blood-brain barrier. - Computational and Structural Biotechnology Journal, 21, 758-768.
https://doi.org/10.1016/j.csbj.2022.12.019

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 Creators:
Semyachkina-Glushkovskaya, O.V.1, Author
Karavaev, A.S.1, Author
Prokhorov, M.D.1, Author
Runnova, A.E.1, Author
Borovkova, E.I.1, Author
Yu.M., Ishbulatov1, Author
Hramkov, A.N.1, Author
Kulminskiy, D.D.1, Author
Semenova, N.I.1, Author
Sergeev, K.S.1, Author
Slepnev, A.V.1, Author
Yu., Sitnikova E.1, Author
Zhuravlev, M.O.1, Author
Fedosov, I.V.1, Author
Shirokov, A.A.1, Author
Blokhina, I.A.1, Author
Dubrovski, A.I.1, Author
Terskov, A.V.1, Author
Khorovodov, A.P.1, Author
Ageev, V.B.1, Author
Elovenko, D.A.1, AuthorEvsukova, A.S.1, AuthorAdushkina, V.V.1, AuthorTelnova, V.V.1, AuthorPostnov, D.E.1, AuthorPenzel, T.U.1, AuthorKurths, Jürgen2, Author               more..
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Abstract: The lymphatic drainage system of the brain (LDSB) is the removal of metabolites and wastes from its tissues. A dysfunction of LDSB is an important sign of aging, brain oncology, the Alzheimer's and Parkinson's diseases. The development of new strategies for diagnosis of LDSB injuries can improve prevention of age-related cerebral amyloid angiopathy, neurodegenerative and cerebrovascular diseases. There are two conditions, such as deep sleep and opening of the blood-brain-barrier (OBBB) associated with the LDSB activation. A promising candidate for measurement of LDSB could be electroencephalography (EEG). In this pilot study on rats, we tested the hypothesis, whether deep sleep and OBBB can be an informative platform for an effective extracting of information about the LDSB functions. Using the nonlinear analysis of EEG dynamics and machine learning technology, we discovered that the LDSB activation during OBBB and sleep is associated with similar changes in the EEG θ-activity. The OBBB causes the higher LDSB activation vs. sleep that is accompanied by specific changes in the low frequency EEG activity extracted by the power spectra analysis of the EEG dynamics combined with the coherence function. Thus, our findings demonstrate a link between neural activity associated with the LDSB activation during sleep and OBBB that is an important informative platform for extraction of the EEG-biomarkers of the LDSB activity. These results open new perspectives for the development of technology for the LDSB diagnostics that would open a novel era in the prognosis of brain diseases caused by the LDSB disorders, including OBBB.

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Language(s): eng - English
 Dates: 2023-01-052023-01-05
 Publication Status: Finally published
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.csbj.2022.12.019
MDB-ID: No data to archive
PIKDOMAIN: RD4 - Complexity Science
Organisational keyword: RD4 - Complexity Science
Research topic keyword: Complex Networks
Research topic keyword: Health
Research topic keyword: Nonlinear Dynamics
Model / method: Nonlinear Data Analysis
OATYPE: Gold Open Access
 Degree: -

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Title: Computational and Structural Biotechnology Journal
Source Genre: Journal, SCI, Scopus
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Publ. Info: -
Pages: - Volume / Issue: 21 Sequence Number: - Start / End Page: 758 - 768 Identifier: CoNE: https://publications.pik-potsdam.de/cone/journals/resource/2001-0370
Publisher: Elsevier