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  Photomodulation of Lymphatic Delivery of Bevacizumab to the Brain: The Role of Singlet Oxygen

Semyachkina-Glushkovskaya, O., Diduk, S., Anna, E., Elina, D., Artem, K., Khorovodov, A., Shirokov, A., Fedosov, I., Dubrovsky, A., Blokhina, I., Terskov, A., Karandin, G., Evsukova, A., Tsven, A., Telnova, V., Afranovich, I., Sokolovski, S., Rafailov, E., Kurths, J. (2022): Photomodulation of Lymphatic Delivery of Bevacizumab to the Brain: The Role of Singlet Oxygen. - In: Scholkmann, F., LaManna, J., Wolf, U. (Eds.), Oxygen Transport to Tissue XLIII, (Advances in Experimental Medicine and Biology ; 1395), Cham : Springer, 53-57.
https://doi.org/10.1007/978-3-031-14190-4_9

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Item Permalink: https://publications.pik-potsdam.de/pubman/item/item_27966 Version Permalink: https://publications.pik-potsdam.de/pubman/item/item_27966_1
Genre: Book Chapter

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 Creators:
Semyachkina-Glushkovskaya, Oxana1, Author
Diduk, Sergey1, Author
Anna, Eroshova1, Author
Elina, Dosadina1, Author
Artem, Kruglov1, Author
Khorovodov, Alexander1, Author
Shirokov, Alexander1, Author
Fedosov, Ivan1, Author
Dubrovsky, Alexander1, Author
Blokhina, Inna1, Author
Terskov, Andrey1, Author
Karandin, Georgy1, Author
Evsukova, Arina1, Author
Tsven, Anna1, Author
Telnova, Valeria1, Author
Afranovich, Ilana1, Author
Sokolovski, Sergey1, Author
Rafailov, Edik1, Author
Kurths, Jürgen2, Author              
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Abstract: The blood-brain barrier (BBB) poses a significant challenge for drug delivery to the brain. Therefore, the development of safe methods for an effective delivery of medications to the brain can be a revolutionary step in overcoming this limitation. Using a quantum-dot-based 1267 nm laser (photosensitiser-free generation of singlet oxygen), we clearly show the photostimulation of lymphatic delivery of bevacizumab (BMZ) to the brain tissues and the meninges. These pilot findings open promising perspectives for photomodulation of a lymphatic brain drug delivery bypassing the BBB, and potentially enabling a breakthrough strategy in therapy of glioma using BMZ and other chemotherapy drugs.

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Language(s): eng - English
 Dates: 2022-12-182022
 Publication Status: Finally published
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/978-3-031-14190-4_9
MDB-ID: No data to archive
PIKDOMAIN: RD4 - Complexity Science
Organisational keyword: RD4 - Complexity Science
Research topic keyword: Health
Research topic keyword: Nonlinear Dynamics
Model / method: Nonlinear Data Analysis
Working Group: Network- and machine-learning-based prediction of extreme events
 Degree: -

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Title: Oxygen Transport to Tissue XLIII
Source Genre: Book
 Creator(s):
Scholkmann, Felix1, Editor
LaManna, Joseph1, Editor
Wolf, Ursula1, Editor
Affiliations:
1 External Organizations, ou_persistent22            
Publ. Info: Cham : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 53 - 57 Identifier: ISBN: 978-3-031-14189-8
ISBN: 978-3-031-14190-4

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Title: Advances in Experimental Medicine and Biology
Source Genre: Series
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Publ. Info: -
Pages: - Volume / Issue: 1395 Sequence Number: - Start / End Page: - Identifier: -