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  Photostimulation of extravasation of Beta-Amyloid through the model of blood-brain barrier

Zinchenko, E., Klimova, M., Mamedova, A., Agranovich, I., Blokhina, I., Antonova, T., Terskov, A., Shirokov, A., Navolokin, N., Morgun, A., Osipova, E., Boytsova, E., Yu, T., Zhu, D., Kurths, J., Semyachkina-Glushkovskaya, O. (2020): Photostimulation of extravasation of Beta-Amyloid through the model of blood-brain barrier. - Electronics, 9, 6, 1056.
https://doi.org/10.3390/electronics9061056

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 Creators:
Zinchenko, Ekaterina1, Author
Klimova, Maria1, Author
Mamedova, Aysel1, Author
Agranovich, Ilana1, Author
Blokhina, Inna1, Author
Antonova, Tatiana1, Author
Terskov, Andrey1, Author
Shirokov, Alexander1, Author
Navolokin, Nikita1, Author
Morgun, Andrey1, Author
Osipova, Elena1, Author
Boytsova, Elizaveta1, Author
Yu, Tingting1, Author
Zhu, Dan1, Author
Kurths, Jürgen2, Author              
Semyachkina-Glushkovskaya, Oxana1, Author
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1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Abstract: Alzheimer’s disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. Phototherapy might be a new promising and alternative strategy for the effective treatment of AD, and has been actively discussed over two decades. However, the mechanisms of therapeutic photostimulation (PS) effects on subjects with AD remain poorly understood. The goal of this study was to determine the mechanisms of therapeutic PS effects in beta-amyloid (Aβ)-injected mice. The neurological severity score and the new object recognition tests demonstrate that PS 9 J/cm2 attenuates the memory and neurological deficit in mice with AD. The immunohistochemical assay revealed a decrease in the level of Aβ in the brain and an increase of Aβ in the deep cervical lymph nodes obtained from mice with AD after PS. Using the in vitro model of the blood-brain barrier (BBB), we show a PS-mediated decrease in transendothelial resistance and in the expression of tight junction proteins as well an increase in the BBB permeability to Aβ. These findings suggest that a PS-mediated BBB opening and the activation of the lymphatic clearance of Aβ from the brain might be a crucial mechanism underlying therapeutic effects of PS in mice with AD. These pioneering data open new strategies in the development of non-pharmacological methods for therapy of AD and contribute to a better understanding of the PS effects on the central nervous system. View Full-Text

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 Dates: 2020-06-262020
 Publication Status: Finally published
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3390/electronics9061056
MDB-ID: No data to archive
PIKDOMAIN: RD4 - Complexity Science
Research topic keyword: Health
Research topic keyword: Nonlinear Dynamics
Organisational keyword: RD4 - Complexity Science
Working Group: Network- and machine-learning-based prediction of extreme events
 Degree: -

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Title: Electronics
Source Genre: Journal, SCI, Scopus, oa
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Pages: - Volume / Issue: 9 (6) Sequence Number: 1056 Start / End Page: - Identifier: Other: MDPI AG
Other: 2079-9292
CoNE: https://publications.pik-potsdam.de/cone/journals/resource/electronics
Publisher: MDPI