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  Low-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma

Semyachkina-Glushkovskaya, O., Bragin, D., Bragina, O., Socolovski, S., Shirokov, A., Fedosov, I., Ageev, V., Blokhina, I., Dubrovsky, A., Telnova, V., Terskov, A., Khorovodov, A., Elovenko, D., Evsukova, A., Zhoy, M., Agranovich, I., Vodovozova, E., Alekseeva, A., Kurths, J., Rafailov, E. (2023): Low-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma. - Pharmaceutics, 15, 2, 567.
https://doi.org/10.3390/pharmaceutics15020567

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Semyachkina-Glushkovskaya, Oxana1, Autor
Bragin, Denis1, Autor
Bragina, Olga1, Autor
Socolovski, Sergey1, Autor
Shirokov, Alexander1, Autor
Fedosov, Ivan1, Autor
Ageev, Vasily1, Autor
Blokhina, Inna1, Autor
Dubrovsky, Alexander1, Autor
Telnova, Valeria1, Autor
Terskov, Andrey1, Autor
Khorovodov, Alexander1, Autor
Elovenko, Daria1, Autor
Evsukova, Arina1, Autor
Zhoy, Maria1, Autor
Agranovich, Ilana1, Autor
Vodovozova, Elena1, Autor
Alekseeva, Anna1, Autor
Kurths, Jürgen2, Autor              
Rafailov, Edik1, Autor
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, Potsdam, ou_persistent13              

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 Zusammenfassung: The progress in brain diseases treatment is limited by the blood-brain barrier (BBB), which prevents delivery of the vast majority of drugs from the blood into the brain. In this study, we discover unknown phenomenon of opening of the BBBB (BBBO) by low-level laser treatment (LLLT, 1268 nm) in the mouse cortex. LLLT-BBBO is accompanied by activation of the brain drainage system contributing effective delivery of liposomes into glioblastoma (GBM). The LLLT induces the generation of singlet oxygen without photosensitizers (PSs) in the blood endothelial cells and astrocytes, which can be a trigger mechanism of BBBO. LLLT-BBBO causes activation of the ABC-transport system with a temporal decrease in the expression of tight junction proteins. The BBB recovery is accompanied by activation of neuronal metabolic activity and stabilization of the BBB permeability. LLLT-BBBO can be used as a new opportunity of interstitial PS-free photodynamic therapy (PDT) for modulation of brain tumor immunity and improvement of immuno-therapy for GBM in infants in whom PDT with PSs, radio- and chemotherapy are strongly limited, as well as in adults with a high allergic reaction to PSs.

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Sprache(n): eng - Englisch
 Datum: 2023-02-082023-02-08
 Publikationsstatus: Final veröffentlicht
 Seiten: 21
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.3390/pharmaceutics15020567
MDB-ID: No data to archive
PIKDOMAIN: RD4 - Complexity Science
Organisational keyword: RD4 - Complexity Science
Research topic keyword: Complex Networks
Research topic keyword: Health
Research topic keyword: Nonlinear Dynamics
Model / method: Nonlinear Data Analysis
OATYPE: Gold Open Access
 Art des Abschluß: -

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Titel: Pharmaceutics
Genre der Quelle: Zeitschrift, SCI, Scopus, oa
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Seiten: - Band / Heft: 15 (2) Artikelnummer: 567 Start- / Endseite: - Identifikator: CoNE: https://publications.pik-potsdam.de/cone/journals/resource/1999-4923
Publisher: MDPI