date: 2021-12-15T13:22:41Z
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pdf:docinfo:title: Brain Mechanisms of COVID-19-Sleep Disorders
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dc:description: 2020 and 2021 have been unprecedented years due to the rapid spread of the modified severe acute respiratory syndrome coronavirus around the world. The coronavirus disease 2019 (COVID-19) causes atypical infiltrated pneumonia with many neurological symptoms, and major sleep changes. The exposure of people to stress, such as social confinement and changes in daily routines, is accompanied by various sleep disturbances, known as ?coronasomnia? phenomenon. Sleep disorders induce neuroinflammation, which promotes the blood?brain barrier (BBB) disruption and entry of antigens and inflammatory factors into the brain. Here, we review findings and trends in sleep research in 2020?2021, demonstrating how COVID-19 and sleep disorders can induce BBB leakage via neuroinflammation, which might contribute to the ?coronasomnia? phenomenon. The new studies suggest that the control of sleep hygiene and quality should be incorporated into the rehabilitation of COVID-19 patients. We also discuss perspective strategies for the prevention of COVID-19-related BBB disorders. We demonstrate that sleep might be a novel biomarker of BBB leakage, and the analysis of sleep EEG patterns can be a breakthrough non-invasive technology for diagnosis of the COVID-19-caused BBB disruption.
Keywords: COVID-19-sleep disorders; brain mechanisms; the blood?brain barrier permeability
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subject: 2020 and 2021 have been unprecedented years due to the rapid spread of the modified severe acute respiratory syndrome coronavirus around the world. The coronavirus disease 2019 (COVID-19) causes atypical infiltrated pneumonia with many neurological symptoms, and major sleep changes. The exposure of people to stress, such as social confinement and changes in daily routines, is accompanied by various sleep disturbances, known as ?coronasomnia? phenomenon. Sleep disorders induce neuroinflammation, which promotes the blood?brain barrier (BBB) disruption and entry of antigens and inflammatory factors into the brain. Here, we review findings and trends in sleep research in 2020?2021, demonstrating how COVID-19 and sleep disorders can induce BBB leakage via neuroinflammation, which might contribute to the ?coronasomnia? phenomenon. The new studies suggest that the control of sleep hygiene and quality should be incorporated into the rehabilitation of COVID-19 patients. We also discuss perspective strategies for the prevention of COVID-19-related BBB disorders. We demonstrate that sleep might be a novel biomarker of BBB leakage, and the analysis of sleep EEG patterns can be a breakthrough non-invasive technology for diagnosis of the COVID-19-caused BBB disruption.
dc:creator: Oxana Semyachkina-Glushkovskaya, Aysel Mamedova, Valeria Vinnik, Maria Klimova, Elena Saranceva, Vasily Ageev, Tingting Yu, Dan Zhu, Thomas Penzel and Jürgen Kurths
description: 2020 and 2021 have been unprecedented years due to the rapid spread of the modified severe acute respiratory syndrome coronavirus around the world. The coronavirus disease 2019 (COVID-19) causes atypical infiltrated pneumonia with many neurological symptoms, and major sleep changes. The exposure of people to stress, such as social confinement and changes in daily routines, is accompanied by various sleep disturbances, known as ?coronasomnia? phenomenon. Sleep disorders induce neuroinflammation, which promotes the blood?brain barrier (BBB) disruption and entry of antigens and inflammatory factors into the brain. Here, we review findings and trends in sleep research in 2020?2021, demonstrating how COVID-19 and sleep disorders can induce BBB leakage via neuroinflammation, which might contribute to the ?coronasomnia? phenomenon. The new studies suggest that the control of sleep hygiene and quality should be incorporated into the rehabilitation of COVID-19 patients. We also discuss perspective strategies for the prevention of COVID-19-related BBB disorders. We demonstrate that sleep might be a novel biomarker of BBB leakage, and the analysis of sleep EEG patterns can be a breakthrough non-invasive technology for diagnosis of the COVID-19-caused BBB disruption.
dcterms:created: 2021-06-28T04:25:26Z
Last-Modified: 2021-12-15T13:22:41Z
dcterms:modified: 2021-12-15T13:22:41Z
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title: Brain Mechanisms of COVID-19-Sleep Disorders
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pdf:docinfo:keywords: COVID-19-sleep disorders; brain mechanisms; the blood?brain barrier permeability
pdf:docinfo:modified: 2021-12-15T13:22:41Z
meta:save-date: 2021-12-15T13:22:41Z
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dc:title: Brain Mechanisms of COVID-19-Sleep Disorders
modified: 2021-12-15T13:22:41Z
cp:subject: 2020 and 2021 have been unprecedented years due to the rapid spread of the modified severe acute respiratory syndrome coronavirus around the world. The coronavirus disease 2019 (COVID-19) causes atypical infiltrated pneumonia with many neurological symptoms, and major sleep changes. The exposure of people to stress, such as social confinement and changes in daily routines, is accompanied by various sleep disturbances, known as ?coronasomnia? phenomenon. Sleep disorders induce neuroinflammation, which promotes the blood?brain barrier (BBB) disruption and entry of antigens and inflammatory factors into the brain. Here, we review findings and trends in sleep research in 2020?2021, demonstrating how COVID-19 and sleep disorders can induce BBB leakage via neuroinflammation, which might contribute to the ?coronasomnia? phenomenon. The new studies suggest that the control of sleep hygiene and quality should be incorporated into the rehabilitation of COVID-19 patients. We also discuss perspective strategies for the prevention of COVID-19-related BBB disorders. We demonstrate that sleep might be a novel biomarker of BBB leakage, and the analysis of sleep EEG patterns can be a breakthrough non-invasive technology for diagnosis of the COVID-19-caused BBB disruption.
pdf:docinfo:subject: 2020 and 2021 have been unprecedented years due to the rapid spread of the modified severe acute respiratory syndrome coronavirus around the world. The coronavirus disease 2019 (COVID-19) causes atypical infiltrated pneumonia with many neurological symptoms, and major sleep changes. The exposure of people to stress, such as social confinement and changes in daily routines, is accompanied by various sleep disturbances, known as ?coronasomnia? phenomenon. Sleep disorders induce neuroinflammation, which promotes the blood?brain barrier (BBB) disruption and entry of antigens and inflammatory factors into the brain. Here, we review findings and trends in sleep research in 2020?2021, demonstrating how COVID-19 and sleep disorders can induce BBB leakage via neuroinflammation, which might contribute to the ?coronasomnia? phenomenon. The new studies suggest that the control of sleep hygiene and quality should be incorporated into the rehabilitation of COVID-19 patients. We also discuss perspective strategies for the prevention of COVID-19-related BBB disorders. We demonstrate that sleep might be a novel biomarker of BBB leakage, and the analysis of sleep EEG patterns can be a breakthrough non-invasive technology for diagnosis of the COVID-19-caused BBB disruption.
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pdf:docinfo:creator: Oxana Semyachkina-Glushkovskaya, Aysel Mamedova, Valeria Vinnik, Maria Klimova, Elena Saranceva, Vasily Ageev, Tingting Yu, Dan Zhu, Thomas Penzel and Jürgen Kurths
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creator: Oxana Semyachkina-Glushkovskaya, Aysel Mamedova, Valeria Vinnik, Maria Klimova, Elena Saranceva, Vasily Ageev, Tingting Yu, Dan Zhu, Thomas Penzel and Jürgen Kurths
meta:author: Oxana Semyachkina-Glushkovskaya, Aysel Mamedova, Valeria Vinnik, Maria Klimova, Elena Saranceva, Vasily Ageev, Tingting Yu, Dan Zhu, Thomas Penzel and Jürgen Kurths
dc:subject: COVID-19-sleep disorders; brain mechanisms; the blood?brain barrier permeability
meta:creation-date: 2021-06-28T04:25:26Z
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meta:keyword: COVID-19-sleep disorders; brain mechanisms; the blood?brain barrier permeability
Author: Oxana Semyachkina-Glushkovskaya, Aysel Mamedova, Valeria Vinnik, Maria Klimova, Elena Saranceva, Vasily Ageev, Tingting Yu, Dan Zhu, Thomas Penzel and Jürgen Kurths
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