date: 2022-06-01T09:19:14Z
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pdf:docinfo:title: Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer?s Disease
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dc:description: The deposition of amyloid- (A) in the brain is a risk factor for Alzheimer?s disease (AD). Therefore, new strategies for the stimulation of A clearance from the brain can be useful in preventing AD. Transcranial photostimulation (PS) is considered a promising method for AD therapy. In our previous studies, we clearly demonstrated the PS-mediated stimulation of lymphatic clearing functions, including A removal from the brain. There is increasing evidence that sleep plays an important role in A clearance. Here, we tested our hypothesis that PS at night can stimulate A clearance from the brain more effectively than PS during the day. Our results on healthy mice show that A clearance from the brain occurs faster at night than during wakefulness. The PS course at night improves memory and reduces A accumulation in the brain of AD mice more effectively than the PS course during the day. Our results suggest that night PS is a more promising candidate as an effective method in preventing AD than daytime PS. These data are an important informative platform for the development of new noninvasive and nonpharmacological technologies for AD therapy as well as for preventing A accumulation in the brain of people with disorder of A metabolism, sleep deficit, elderly age, and jet lag.
Keywords: amyloid-; night clearance; transcranial photostimulation; lymphatic system
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subject: The deposition of amyloid- (A) in the brain is a risk factor for Alzheimer?s disease (AD). Therefore, new strategies for the stimulation of A clearance from the brain can be useful in preventing AD. Transcranial photostimulation (PS) is considered a promising method for AD therapy. In our previous studies, we clearly demonstrated the PS-mediated stimulation of lymphatic clearing functions, including A removal from the brain. There is increasing evidence that sleep plays an important role in A clearance. Here, we tested our hypothesis that PS at night can stimulate A clearance from the brain more effectively than PS during the day. Our results on healthy mice show that A clearance from the brain occurs faster at night than during wakefulness. The PS course at night improves memory and reduces A accumulation in the brain of AD mice more effectively than the PS course during the day. Our results suggest that night PS is a more promising candidate as an effective method in preventing AD than daytime PS. These data are an important informative platform for the development of new noninvasive and nonpharmacological technologies for AD therapy as well as for preventing A accumulation in the brain of people with disorder of A metabolism, sleep deficit, elderly age, and jet lag.
dc:creator: Oxana Semyachkina-Glushkovskaya, Thomas Penzel, Inna Blokhina, Alexander Khorovodov, Ivan Fedosov, Tingting Yu, Georgy Karandin, Arina Evsukova, Dariya Elovenko, Viktoria Adushkina, Alexander Shirokov, Alexander Dubrovskii, Andrey Terskov, Nikita Navolokin, Maria Tzoy, Vasily Ageev, Ilana Agranovich, Valeria Telnova, Anna Tsven and Jürgen Kurths
description: The deposition of amyloid- (A) in the brain is a risk factor for Alzheimer?s disease (AD). Therefore, new strategies for the stimulation of A clearance from the brain can be useful in preventing AD. Transcranial photostimulation (PS) is considered a promising method for AD therapy. In our previous studies, we clearly demonstrated the PS-mediated stimulation of lymphatic clearing functions, including A removal from the brain. There is increasing evidence that sleep plays an important role in A clearance. Here, we tested our hypothesis that PS at night can stimulate A clearance from the brain more effectively than PS during the day. Our results on healthy mice show that A clearance from the brain occurs faster at night than during wakefulness. The PS course at night improves memory and reduces A accumulation in the brain of AD mice more effectively than the PS course during the day. Our results suggest that night PS is a more promising candidate as an effective method in preventing AD than daytime PS. These data are an important informative platform for the development of new noninvasive and nonpharmacological technologies for AD therapy as well as for preventing A accumulation in the brain of people with disorder of A metabolism, sleep deficit, elderly age, and jet lag.
dcterms:created: 2021-11-24T11:32:51Z
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title: Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer?s Disease
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pdf:docinfo:keywords: amyloid-; night clearance; transcranial photostimulation; lymphatic system
pdf:docinfo:modified: 2022-06-01T09:19:14Z
meta:save-date: 2022-06-01T09:19:14Z
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dc:title: Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer?s Disease
modified: 2022-06-01T09:19:14Z
cp:subject: The deposition of amyloid- (A) in the brain is a risk factor for Alzheimer?s disease (AD). Therefore, new strategies for the stimulation of A clearance from the brain can be useful in preventing AD. Transcranial photostimulation (PS) is considered a promising method for AD therapy. In our previous studies, we clearly demonstrated the PS-mediated stimulation of lymphatic clearing functions, including A removal from the brain. There is increasing evidence that sleep plays an important role in A clearance. Here, we tested our hypothesis that PS at night can stimulate A clearance from the brain more effectively than PS during the day. Our results on healthy mice show that A clearance from the brain occurs faster at night than during wakefulness. The PS course at night improves memory and reduces A accumulation in the brain of AD mice more effectively than the PS course during the day. Our results suggest that night PS is a more promising candidate as an effective method in preventing AD than daytime PS. These data are an important informative platform for the development of new noninvasive and nonpharmacological technologies for AD therapy as well as for preventing A accumulation in the brain of people with disorder of A metabolism, sleep deficit, elderly age, and jet lag.
pdf:docinfo:subject: The deposition of amyloid- (A) in the brain is a risk factor for Alzheimer?s disease (AD). Therefore, new strategies for the stimulation of A clearance from the brain can be useful in preventing AD. Transcranial photostimulation (PS) is considered a promising method for AD therapy. In our previous studies, we clearly demonstrated the PS-mediated stimulation of lymphatic clearing functions, including A removal from the brain. There is increasing evidence that sleep plays an important role in A clearance. Here, we tested our hypothesis that PS at night can stimulate A clearance from the brain more effectively than PS during the day. Our results on healthy mice show that A clearance from the brain occurs faster at night than during wakefulness. The PS course at night improves memory and reduces A accumulation in the brain of AD mice more effectively than the PS course during the day. Our results suggest that night PS is a more promising candidate as an effective method in preventing AD than daytime PS. These data are an important informative platform for the development of new noninvasive and nonpharmacological technologies for AD therapy as well as for preventing A accumulation in the brain of people with disorder of A metabolism, sleep deficit, elderly age, and jet lag.
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pdf:docinfo:creator: Oxana Semyachkina-Glushkovskaya, Thomas Penzel, Inna Blokhina, Alexander Khorovodov, Ivan Fedosov, Tingting Yu, Georgy Karandin, Arina Evsukova, Dariya Elovenko, Viktoria Adushkina, Alexander Shirokov, Alexander Dubrovskii, Andrey Terskov, Nikita Navolokin, Maria Tzoy, Vasily Ageev, Ilana Agranovich, Valeria Telnova, Anna Tsven and Jürgen Kurths
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creator: Oxana Semyachkina-Glushkovskaya, Thomas Penzel, Inna Blokhina, Alexander Khorovodov, Ivan Fedosov, Tingting Yu, Georgy Karandin, Arina Evsukova, Dariya Elovenko, Viktoria Adushkina, Alexander Shirokov, Alexander Dubrovskii, Andrey Terskov, Nikita Navolokin, Maria Tzoy, Vasily Ageev, Ilana Agranovich, Valeria Telnova, Anna Tsven and Jürgen Kurths
meta:author: Oxana Semyachkina-Glushkovskaya, Thomas Penzel, Inna Blokhina, Alexander Khorovodov, Ivan Fedosov, Tingting Yu, Georgy Karandin, Arina Evsukova, Dariya Elovenko, Viktoria Adushkina, Alexander Shirokov, Alexander Dubrovskii, Andrey Terskov, Nikita Navolokin, Maria Tzoy, Vasily Ageev, Ilana Agranovich, Valeria Telnova, Anna Tsven and Jürgen Kurths
dc:subject: amyloid-; night clearance; transcranial photostimulation; lymphatic system
meta:creation-date: 2021-11-24T11:32:51Z
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Author: Oxana Semyachkina-Glushkovskaya, Thomas Penzel, Inna Blokhina, Alexander Khorovodov, Ivan Fedosov, Tingting Yu, Georgy Karandin, Arina Evsukova, Dariya Elovenko, Viktoria Adushkina, Alexander Shirokov, Alexander Dubrovskii, Andrey Terskov, Nikita Navolokin, Maria Tzoy, Vasily Ageev, Ilana Agranovich, Valeria Telnova, Anna Tsven and Jürgen Kurths
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