date: 2022-11-28T02:22:28Z
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pdf:docinfo:title: Photodynamic Opening of the Blood?Brain Barrier and the Meningeal Lymphatic System: The New Niche in Immunotherapy for Brain Tumors
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Keywords: photodynamic therapy; blood-brain barrier; meningeal lymphatic vessels; glioblastoma; immunotherapy for brain tumors
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subject: Photodynamic therapy (PDT) is a promising add-on therapy to the current standard of care for patients with glioblastoma (GBM). The traditional explanation of the anti-cancer PDT effects involves the PDT-induced generation of a singlet oxygen in the GBM cells, which causes tumor cell death and microvasculature collapse. Recently, new vascular mechanisms of PDT associated with opening of the blood?brain barrier (OBBB) and the activation of functions of the meningeal lymphatic vessels have been discovered. In this review, we highlight the emerging trends and future promises of immunotherapy for brain tumors and discuss PDT-OBBB as a new niche and an important informative platform for the development of innovative pharmacological strategies for the modulation of brain tumor immunity and the improvement of immunotherapy for GBM.
dc:creator: Oxana Semyachkina-Glushkovskaya, Andrey Terskov, Alexander Khorovodov, Valeria Telnova, Inna Blokhina, Elena Saranceva and Jürgen Kurths
dcterms:created: 2022-11-28T02:19:42Z
Last-Modified: 2022-11-28T02:22:28Z
dcterms:modified: 2022-11-28T02:22:28Z
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title: Photodynamic Opening of the Blood?Brain Barrier and the Meningeal Lymphatic System: The New Niche in Immunotherapy for Brain Tumors
Last-Save-Date: 2022-11-28T02:22:28Z
pdf:docinfo:creator_tool: LaTeX with hyperref
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pdf:docinfo:keywords: photodynamic therapy; blood-brain barrier; meningeal lymphatic vessels; glioblastoma; immunotherapy for brain tumors
pdf:docinfo:modified: 2022-11-28T02:22:28Z
meta:save-date: 2022-11-28T02:22:28Z
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dc:title: Photodynamic Opening of the Blood?Brain Barrier and the Meningeal Lymphatic System: The New Niche in Immunotherapy for Brain Tumors
modified: 2022-11-28T02:22:28Z
cp:subject: Photodynamic therapy (PDT) is a promising add-on therapy to the current standard of care for patients with glioblastoma (GBM). The traditional explanation of the anti-cancer PDT effects involves the PDT-induced generation of a singlet oxygen in the GBM cells, which causes tumor cell death and microvasculature collapse. Recently, new vascular mechanisms of PDT associated with opening of the blood?brain barrier (OBBB) and the activation of functions of the meningeal lymphatic vessels have been discovered. In this review, we highlight the emerging trends and future promises of immunotherapy for brain tumors and discuss PDT-OBBB as a new niche and an important informative platform for the development of innovative pharmacological strategies for the modulation of brain tumor immunity and the improvement of immunotherapy for GBM.
pdf:docinfo:subject: Photodynamic therapy (PDT) is a promising add-on therapy to the current standard of care for patients with glioblastoma (GBM). The traditional explanation of the anti-cancer PDT effects involves the PDT-induced generation of a singlet oxygen in the GBM cells, which causes tumor cell death and microvasculature collapse. Recently, new vascular mechanisms of PDT associated with opening of the blood?brain barrier (OBBB) and the activation of functions of the meningeal lymphatic vessels have been discovered. In this review, we highlight the emerging trends and future promises of immunotherapy for brain tumors and discuss PDT-OBBB as a new niche and an important informative platform for the development of innovative pharmacological strategies for the modulation of brain tumor immunity and the improvement of immunotherapy for GBM.
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pdf:docinfo:creator: Oxana Semyachkina-Glushkovskaya, Andrey Terskov, Alexander Khorovodov, Valeria Telnova, Inna Blokhina, Elena Saranceva and Jürgen Kurths
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creator: Oxana Semyachkina-Glushkovskaya, Andrey Terskov, Alexander Khorovodov, Valeria Telnova, Inna Blokhina, Elena Saranceva and Jürgen Kurths
meta:author: Oxana Semyachkina-Glushkovskaya, Andrey Terskov, Alexander Khorovodov, Valeria Telnova, Inna Blokhina, Elena Saranceva and Jürgen Kurths
dc:subject: photodynamic therapy; blood-brain barrier; meningeal lymphatic vessels; glioblastoma; immunotherapy for brain tumors
meta:creation-date: 2022-11-28T02:19:42Z
created: Mon Nov 28 03:19:42 CET 2022
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Creation-Date: 2022-11-28T02:19:42Z
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meta:keyword: photodynamic therapy; blood-brain barrier; meningeal lymphatic vessels; glioblastoma; immunotherapy for brain tumors
Author: Oxana Semyachkina-Glushkovskaya, Andrey Terskov, Alexander Khorovodov, Valeria Telnova, Inna Blokhina, Elena Saranceva and Jürgen Kurths
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pdf:docinfo:created: 2022-11-28T02:19:42Z