date: 2023-02-17T05:59:37Z pdf:PDFVersion: 1.7 pdf:docinfo:title: Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases xmp:CreatorTool: LaTeX with hyperref Keywords: brain diseases; meningeal lymphatic vessels; photobiomodulation access_permission:modify_annotations: true access_permission:can_print_degraded: true subject: Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease in MLV function is associated with Alzheimer?s and Parkinson?s diseases, intracranial hemorrhages, brain tumors and trauma. Since the BWRS is activated during sleep, a new idea is now being actively discussed in the scientific community: night stimulation of the BWRS might be an innovative and promising strategy for neurorehabilitation medicine. This review highlights new trends in photobiomodulation of the BWRS/MLVs during deep sleep as a breakthrough technology for the effective removal of wastes and unnecessary compounds from the brain in order to increase the neuroprotection of the CNS as well as to prevent or delay various brain diseases. dc:creator: Oxana Semyachkina-Glushkovskaya, Ivan Fedosov, Thomas Penzel, Dongyu Li, Tingting Yu, Valeria Telnova, Elmira Kaybeleva, Elena Saranceva, Andrey Terskov, Alexander Khorovodov, Inna Blokhina, Jürgen Kurths and Dan Zhu dcterms:created: 2023-02-17T05:54:00Z Last-Modified: 2023-02-17T05:59:37Z dcterms:modified: 2023-02-17T05:59:37Z dc:format: application/pdf; version=1.7 title: Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases Last-Save-Date: 2023-02-17T05:59:37Z pdf:docinfo:creator_tool: LaTeX with hyperref access_permission:fill_in_form: true pdf:docinfo:keywords: brain diseases; meningeal lymphatic vessels; photobiomodulation pdf:docinfo:modified: 2023-02-17T05:59:37Z meta:save-date: 2023-02-17T05:59:37Z pdf:encrypted: false dc:title: Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases modified: 2023-02-17T05:59:37Z cp:subject: Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease in MLV function is associated with Alzheimer?s and Parkinson?s diseases, intracranial hemorrhages, brain tumors and trauma. Since the BWRS is activated during sleep, a new idea is now being actively discussed in the scientific community: night stimulation of the BWRS might be an innovative and promising strategy for neurorehabilitation medicine. This review highlights new trends in photobiomodulation of the BWRS/MLVs during deep sleep as a breakthrough technology for the effective removal of wastes and unnecessary compounds from the brain in order to increase the neuroprotection of the CNS as well as to prevent or delay various brain diseases. pdf:docinfo:subject: Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease in MLV function is associated with Alzheimer?s and Parkinson?s diseases, intracranial hemorrhages, brain tumors and trauma. Since the BWRS is activated during sleep, a new idea is now being actively discussed in the scientific community: night stimulation of the BWRS might be an innovative and promising strategy for neurorehabilitation medicine. This review highlights new trends in photobiomodulation of the BWRS/MLVs during deep sleep as a breakthrough technology for the effective removal of wastes and unnecessary compounds from the brain in order to increase the neuroprotection of the CNS as well as to prevent or delay various brain diseases. Content-Type: application/pdf pdf:docinfo:creator: Oxana Semyachkina-Glushkovskaya, Ivan Fedosov, Thomas Penzel, Dongyu Li, Tingting Yu, Valeria Telnova, Elmira Kaybeleva, Elena Saranceva, Andrey Terskov, Alexander Khorovodov, Inna Blokhina, Jürgen Kurths and Dan Zhu X-Parsed-By: org.apache.tika.parser.DefaultParser creator: Oxana Semyachkina-Glushkovskaya, Ivan Fedosov, Thomas Penzel, Dongyu Li, Tingting Yu, Valeria Telnova, Elmira Kaybeleva, Elena Saranceva, Andrey Terskov, Alexander Khorovodov, Inna Blokhina, Jürgen Kurths and Dan Zhu meta:author: Oxana Semyachkina-Glushkovskaya, Ivan Fedosov, Thomas Penzel, Dongyu Li, Tingting Yu, Valeria Telnova, Elmira Kaybeleva, Elena Saranceva, Andrey Terskov, Alexander Khorovodov, Inna Blokhina, Jürgen Kurths and Dan Zhu dc:subject: brain diseases; meningeal lymphatic vessels; photobiomodulation meta:creation-date: 2023-02-17T05:54:00Z created: Fri Feb 17 06:54:00 CET 2023 access_permission:extract_for_accessibility: true access_permission:assemble_document: true xmpTPg:NPages: 17 Creation-Date: 2023-02-17T05:54:00Z access_permission:extract_content: true access_permission:can_print: true meta:keyword: brain diseases; meningeal lymphatic vessels; photobiomodulation Author: Oxana Semyachkina-Glushkovskaya, Ivan Fedosov, Thomas Penzel, Dongyu Li, Tingting Yu, Valeria Telnova, Elmira Kaybeleva, Elena Saranceva, Andrey Terskov, Alexander Khorovodov, Inna Blokhina, Jürgen Kurths and Dan Zhu producer: pdfTeX-1.40.21 access_permission:can_modify: true pdf:docinfo:producer: pdfTeX-1.40.21 pdf:docinfo:created: 2023-02-17T05:54:00Z