date: 2023-09-05T10:48:50Z
pdf:PDFVersion: 1.7
pdf:docinfo:title: Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain
xmp:CreatorTool: LaTeX with hyperref
Keywords: glioblastoma; phototherapy; quantum-dot 1267 nm laser; NIR laser oxidative celldamaging; lymphatic system
access_permission:modify_annotations: true
access_permission:can_print_degraded: true
subject: Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the most lethal form of brain cancer, with very limited treatment options and a poor prognosis. In this study on rats, we demonstrate that glioblastoma (GBM) growth can be suppressed by photosensitizer-free laser treatment (PS-free-LT) using a quantum-dot-based 1267 nm laser diode. This wavelength, highly absorbed by oxygen, is capable of turning triplet oxygen to singlet form. Applying 1267 nm laser irradiation for a 4 week course with a total dose of 12.7 kJ/cm2 firmly suppresses GBM growth and increases survival rate from 34% to 64%, presumably via LT-activated apoptosis, inhibition of the proliferation of tumor cells, a reduction in intracranial pressure and stimulation of the lymphatic drainage and clearing functions. PS-free-LT is a promising breakthrough technology in non- or minimally invasive therapy for superficial GBMs in infants as well as in adult patients with high photosensitivity or an allergic reaction to PSs.
dc:creator: Oxana Semyachkina-Glushkovskaya, Sergey Sokolovski, Ivan Fedosov, Alexander Shirokov, Nikita Navolokin, Alla Bucharskaya, Inna Blokhina, Andrey Terskov, Alexander Dubrovski, Valeria Telnova, Anna Tzven, Maria Tzoy, Arina Evsukova, Daria Zhlatogosrkaya, Viktoria Adushkina, Alexander Dmitrenko, Maria Manzhaeva, Valeria Krupnova, Alessio Noghero, Denis Bragin, Olga Bragina, Ekaterina Borisova, Jürgen Kurths and Edik Rafailov
dcterms:created: 2023-09-05T10:22:48Z
Last-Modified: 2023-09-05T10:48:50Z
dcterms:modified: 2023-09-05T10:48:50Z
dc:format: application/pdf; version=1.7
title: Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain
Last-Save-Date: 2023-09-05T10:48:50Z
pdf:docinfo:creator_tool: LaTeX with hyperref
access_permission:fill_in_form: true
pdf:docinfo:keywords: glioblastoma; phototherapy; quantum-dot 1267 nm laser; NIR laser oxidative celldamaging; lymphatic system
pdf:docinfo:modified: 2023-09-05T10:48:50Z
meta:save-date: 2023-09-05T10:48:50Z
pdf:encrypted: false
dc:title: Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain
modified: 2023-09-05T10:48:50Z
cp:subject: Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the most lethal form of brain cancer, with very limited treatment options and a poor prognosis. In this study on rats, we demonstrate that glioblastoma (GBM) growth can be suppressed by photosensitizer-free laser treatment (PS-free-LT) using a quantum-dot-based 1267 nm laser diode. This wavelength, highly absorbed by oxygen, is capable of turning triplet oxygen to singlet form. Applying 1267 nm laser irradiation for a 4 week course with a total dose of 12.7 kJ/cm2 firmly suppresses GBM growth and increases survival rate from 34% to 64%, presumably via LT-activated apoptosis, inhibition of the proliferation of tumor cells, a reduction in intracranial pressure and stimulation of the lymphatic drainage and clearing functions. PS-free-LT is a promising breakthrough technology in non- or minimally invasive therapy for superficial GBMs in infants as well as in adult patients with high photosensitivity or an allergic reaction to PSs.
pdf:docinfo:subject: Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the most lethal form of brain cancer, with very limited treatment options and a poor prognosis. In this study on rats, we demonstrate that glioblastoma (GBM) growth can be suppressed by photosensitizer-free laser treatment (PS-free-LT) using a quantum-dot-based 1267 nm laser diode. This wavelength, highly absorbed by oxygen, is capable of turning triplet oxygen to singlet form. Applying 1267 nm laser irradiation for a 4 week course with a total dose of 12.7 kJ/cm2 firmly suppresses GBM growth and increases survival rate from 34% to 64%, presumably via LT-activated apoptosis, inhibition of the proliferation of tumor cells, a reduction in intracranial pressure and stimulation of the lymphatic drainage and clearing functions. PS-free-LT is a promising breakthrough technology in non- or minimally invasive therapy for superficial GBMs in infants as well as in adult patients with high photosensitivity or an allergic reaction to PSs.
Content-Type: application/pdf
pdf:docinfo:creator: Oxana Semyachkina-Glushkovskaya, Sergey Sokolovski, Ivan Fedosov, Alexander Shirokov, Nikita Navolokin, Alla Bucharskaya, Inna Blokhina, Andrey Terskov, Alexander Dubrovski, Valeria Telnova, Anna Tzven, Maria Tzoy, Arina Evsukova, Daria Zhlatogosrkaya, Viktoria Adushkina, Alexander Dmitrenko, Maria Manzhaeva, Valeria Krupnova, Alessio Noghero, Denis Bragin, Olga Bragina, Ekaterina Borisova, Jürgen Kurths and Edik Rafailov
X-Parsed-By: org.apache.tika.parser.DefaultParser
creator: Oxana Semyachkina-Glushkovskaya, Sergey Sokolovski, Ivan Fedosov, Alexander Shirokov, Nikita Navolokin, Alla Bucharskaya, Inna Blokhina, Andrey Terskov, Alexander Dubrovski, Valeria Telnova, Anna Tzven, Maria Tzoy, Arina Evsukova, Daria Zhlatogosrkaya, Viktoria Adushkina, Alexander Dmitrenko, Maria Manzhaeva, Valeria Krupnova, Alessio Noghero, Denis Bragin, Olga Bragina, Ekaterina Borisova, Jürgen Kurths and Edik Rafailov
meta:author: Oxana Semyachkina-Glushkovskaya, Sergey Sokolovski, Ivan Fedosov, Alexander Shirokov, Nikita Navolokin, Alla Bucharskaya, Inna Blokhina, Andrey Terskov, Alexander Dubrovski, Valeria Telnova, Anna Tzven, Maria Tzoy, Arina Evsukova, Daria Zhlatogosrkaya, Viktoria Adushkina, Alexander Dmitrenko, Maria Manzhaeva, Valeria Krupnova, Alessio Noghero, Denis Bragin, Olga Bragina, Ekaterina Borisova, Jürgen Kurths and Edik Rafailov
dc:subject: glioblastoma; phototherapy; quantum-dot 1267 nm laser; NIR laser oxidative celldamaging; lymphatic system
meta:creation-date: 2023-09-05T10:22:48Z
created: Tue Sep 05 12:22:48 CEST 2023
access_permission:extract_for_accessibility: true
access_permission:assemble_document: true
xmpTPg:NPages: 25
Creation-Date: 2023-09-05T10:22:48Z
access_permission:extract_content: true
access_permission:can_print: true
meta:keyword: glioblastoma; phototherapy; quantum-dot 1267 nm laser; NIR laser oxidative celldamaging; lymphatic system
Author: Oxana Semyachkina-Glushkovskaya, Sergey Sokolovski, Ivan Fedosov, Alexander Shirokov, Nikita Navolokin, Alla Bucharskaya, Inna Blokhina, Andrey Terskov, Alexander Dubrovski, Valeria Telnova, Anna Tzven, Maria Tzoy, Arina Evsukova, Daria Zhlatogosrkaya, Viktoria Adushkina, Alexander Dmitrenko, Maria Manzhaeva, Valeria Krupnova, Alessio Noghero, Denis Bragin, Olga Bragina, Ekaterina Borisova, Jürgen Kurths and Edik Rafailov
producer: pdfTeX-1.40.21
access_permission:can_modify: true
pdf:docinfo:producer: pdfTeX-1.40.21
pdf:docinfo:created: 2023-09-05T10:22:48Z