date: 2023-11-02T02:23:24Z
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pdf:docinfo:title: Machine Learning Technology for EEG-Forecast of the Blood?Brain Barrier Leakage and the Activation of the Brain?s Drainage System during Isoflurane Anesthesia
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Keywords: anesthesia; machine learning technology; spectral power analysis; blood?brain barrier; brain?s drainage system
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subject: Anesthesia enables the painless performance of complex surgical procedures. However, the effects of anesthesia on the brain may not be limited only by its duration. Also, anesthetic agents may cause long-lasting changes in the brain. There is growing evidence that anesthesia can disrupt the integrity of the blood?brain barrier (BBB), leading to neuroinflammation and neurotoxicity. However, there are no widely used methods for real-time BBB monitoring during surgery. The development of technologies for an express diagnosis of the opening of the BBB (OBBB) is a challenge for reducing post-surgical/anesthesia consequences. In this study on male rats, we demonstrate a successful application of machine learning technology, such as artificial neural networks (ANNs), to recognize the OBBB induced by isoflurane, which is widely used in surgery. The ANNs were trained on our previously presented data obtained on the sound-induced OBBB with an 85% testing accuracy. Using an optical and nonlinear analysis of the OBBB, we found that 1% isoflurane does not induce any changes in the BBB, while 4% isoflurane caused significant BBB leakage in all tested rats. Both 1% and 4% isoflurane stimulate the brain?s drainage system (BDS) in a dose-related manner. We show that ANNs can recognize the OBBB induced by 4% isoflurane in 57% of rats and BDS activation induced by 1% isoflurane in 81% of rats. These results open new perspectives for the development of clinically significant bedside technologies for EEG-monitoring of OBBB and BDS.
dc:creator: Oxana Semyachkina-Glushkovskaya, Konstantin Sergeev, Nadezhda Semenova, Andrey Slepnev, Anatoly Karavaev, Alexey Hramkov, Mikhail Prokhorov, Ekaterina Borovkova, Inna Blokhina, Ivan Fedosov, Alexander Shirokov, Alexander Dubrovsky, Andrey Terskov, Maria Manzhaeva, Valeria Krupnova, Alexander Dmitrenko, Daria Zlatogorskaya, Viktoria Adushkina, Arina Evsukova, Matvey Tuzhilkin, Inna Elizarova, Egor Ilyukov, Dmitry Myagkov, Dmitry Tuktarov and Jürgen Kurths
dcterms:created: 2023-11-02T02:15:19Z
Last-Modified: 2023-11-02T02:23:24Z
dcterms:modified: 2023-11-02T02:23:24Z
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title: Machine Learning Technology for EEG-Forecast of the Blood?Brain Barrier Leakage and the Activation of the Brain?s Drainage System during Isoflurane Anesthesia
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pdf:docinfo:keywords: anesthesia; machine learning technology; spectral power analysis; blood?brain barrier; brain?s drainage system
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dc:title: Machine Learning Technology for EEG-Forecast of the Blood?Brain Barrier Leakage and the Activation of the Brain?s Drainage System during Isoflurane Anesthesia
modified: 2023-11-02T02:23:24Z
cp:subject: Anesthesia enables the painless performance of complex surgical procedures. However, the effects of anesthesia on the brain may not be limited only by its duration. Also, anesthetic agents may cause long-lasting changes in the brain. There is growing evidence that anesthesia can disrupt the integrity of the blood?brain barrier (BBB), leading to neuroinflammation and neurotoxicity. However, there are no widely used methods for real-time BBB monitoring during surgery. The development of technologies for an express diagnosis of the opening of the BBB (OBBB) is a challenge for reducing post-surgical/anesthesia consequences. In this study on male rats, we demonstrate a successful application of machine learning technology, such as artificial neural networks (ANNs), to recognize the OBBB induced by isoflurane, which is widely used in surgery. The ANNs were trained on our previously presented data obtained on the sound-induced OBBB with an 85% testing accuracy. Using an optical and nonlinear analysis of the OBBB, we found that 1% isoflurane does not induce any changes in the BBB, while 4% isoflurane caused significant BBB leakage in all tested rats. Both 1% and 4% isoflurane stimulate the brain?s drainage system (BDS) in a dose-related manner. We show that ANNs can recognize the OBBB induced by 4% isoflurane in 57% of rats and BDS activation induced by 1% isoflurane in 81% of rats. These results open new perspectives for the development of clinically significant bedside technologies for EEG-monitoring of OBBB and BDS.
pdf:docinfo:subject: Anesthesia enables the painless performance of complex surgical procedures. However, the effects of anesthesia on the brain may not be limited only by its duration. Also, anesthetic agents may cause long-lasting changes in the brain. There is growing evidence that anesthesia can disrupt the integrity of the blood?brain barrier (BBB), leading to neuroinflammation and neurotoxicity. However, there are no widely used methods for real-time BBB monitoring during surgery. The development of technologies for an express diagnosis of the opening of the BBB (OBBB) is a challenge for reducing post-surgical/anesthesia consequences. In this study on male rats, we demonstrate a successful application of machine learning technology, such as artificial neural networks (ANNs), to recognize the OBBB induced by isoflurane, which is widely used in surgery. The ANNs were trained on our previously presented data obtained on the sound-induced OBBB with an 85% testing accuracy. Using an optical and nonlinear analysis of the OBBB, we found that 1% isoflurane does not induce any changes in the BBB, while 4% isoflurane caused significant BBB leakage in all tested rats. Both 1% and 4% isoflurane stimulate the brain?s drainage system (BDS) in a dose-related manner. We show that ANNs can recognize the OBBB induced by 4% isoflurane in 57% of rats and BDS activation induced by 1% isoflurane in 81% of rats. These results open new perspectives for the development of clinically significant bedside technologies for EEG-monitoring of OBBB and BDS.
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pdf:docinfo:creator: Oxana Semyachkina-Glushkovskaya, Konstantin Sergeev, Nadezhda Semenova, Andrey Slepnev, Anatoly Karavaev, Alexey Hramkov, Mikhail Prokhorov, Ekaterina Borovkova, Inna Blokhina, Ivan Fedosov, Alexander Shirokov, Alexander Dubrovsky, Andrey Terskov, Maria Manzhaeva, Valeria Krupnova, Alexander Dmitrenko, Daria Zlatogorskaya, Viktoria Adushkina, Arina Evsukova, Matvey Tuzhilkin, Inna Elizarova, Egor Ilyukov, Dmitry Myagkov, Dmitry Tuktarov and Jürgen Kurths
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creator: Oxana Semyachkina-Glushkovskaya, Konstantin Sergeev, Nadezhda Semenova, Andrey Slepnev, Anatoly Karavaev, Alexey Hramkov, Mikhail Prokhorov, Ekaterina Borovkova, Inna Blokhina, Ivan Fedosov, Alexander Shirokov, Alexander Dubrovsky, Andrey Terskov, Maria Manzhaeva, Valeria Krupnova, Alexander Dmitrenko, Daria Zlatogorskaya, Viktoria Adushkina, Arina Evsukova, Matvey Tuzhilkin, Inna Elizarova, Egor Ilyukov, Dmitry Myagkov, Dmitry Tuktarov and Jürgen Kurths
meta:author: Oxana Semyachkina-Glushkovskaya, Konstantin Sergeev, Nadezhda Semenova, Andrey Slepnev, Anatoly Karavaev, Alexey Hramkov, Mikhail Prokhorov, Ekaterina Borovkova, Inna Blokhina, Ivan Fedosov, Alexander Shirokov, Alexander Dubrovsky, Andrey Terskov, Maria Manzhaeva, Valeria Krupnova, Alexander Dmitrenko, Daria Zlatogorskaya, Viktoria Adushkina, Arina Evsukova, Matvey Tuzhilkin, Inna Elizarova, Egor Ilyukov, Dmitry Myagkov, Dmitry Tuktarov and Jürgen Kurths
dc:subject: anesthesia; machine learning technology; spectral power analysis; blood?brain barrier; brain?s drainage system
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Author: Oxana Semyachkina-Glushkovskaya, Konstantin Sergeev, Nadezhda Semenova, Andrey Slepnev, Anatoly Karavaev, Alexey Hramkov, Mikhail Prokhorov, Ekaterina Borovkova, Inna Blokhina, Ivan Fedosov, Alexander Shirokov, Alexander Dubrovsky, Andrey Terskov, Maria Manzhaeva, Valeria Krupnova, Alexander Dmitrenko, Daria Zlatogorskaya, Viktoria Adushkina, Arina Evsukova, Matvey Tuzhilkin, Inna Elizarova, Egor Ilyukov, Dmitry Myagkov, Dmitry Tuktarov and Jürgen Kurths
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