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  Lymphatic Clearance from the Blood after Subarachnoid Hemorrhages

Semyachkina-Glushkovskaya, O., Abdurashitov, A., Dubrovsky, A., Shirokov, A., Navolokin, N., Klimova, M., Duarte Torres, E., Khorovodov, A., Mamedova, A., Shareef, A. E., Terskov, A., Saranceva, E., Iskra, T., Kurths, J. (2019): Lymphatic Clearance from the Blood after Subarachnoid Hemorrhages. - In: Luo, Q., Ding, J., Fu, L. (Eds.), Neural Imaging and Sensing 2019, (Proceedings of SPIE ; 10865), Bellingham : Society of Photo-Optical Instrumentation Engineers (SPIE), 108650T.
https://doi.org/10.1117/12.2509065

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Semyachkina-Glushkovskaya, O.1, Autor
Abdurashitov, A.1, Autor
Dubrovsky, A.1, Autor
Shirokov, A.1, Autor
Navolokin, N.1, Autor
Klimova, M.1, Autor
Duarte Torres, E.1, Autor
Khorovodov, A.1, Autor
Mamedova, A.1, Autor
Shareef, A. E.1, Autor
Terskov, A.1, Autor
Saranceva, E.1, Autor
Iskra, T.1, Autor
Kurths, Jürgen2, Autor              
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Zusammenfassung: Here we present preliminary experimental data suggesting about involvement of the meningeal and cervical lymphatics in neurorehabilitation. Using model of hemorrhagic stroke, immunohistochemical analysis and atomic absorption spectroscopy, we clearly demonstrate the lymphatic clearance from the blood after stroke via the meningeal lymphatic vessels with further accumulation of hemosiderin and iron (products of disaggregated hemoglobin) in the deep cervical node (dcLN). The optical coherent tomography (OCT) was used for in vivo monitoring of accumulation of gold nanorods (92 nm in diameter) in the dcLN after their injection into the cisterna magna with the aim of mimicking of the brain clearance from of blood. The both ex vivo and in vivo data show the lymphatic clearance from subjects (the blood/GNRs) injected into the subarachnoid space that might be an important mechanism of neurorehabilitation after the intracranial hemorrhages.

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 Datum: 2019
 Publikationsstatus: Final veröffentlicht
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 Ort, Verlag, Ausgabe: -
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 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1117/12.2509065
PIKDOMAIN: RD4 - Complexity Science
eDoc: 8929
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Titel: Neural Imaging and Sensing 2019
Genre der Quelle: Buch
 Urheber:
Luo, Q.1, Herausgeber
Ding, J.1, Herausgeber
Fu, L.1, Herausgeber
Affiliations:
1 External Organizations, ou_persistent22            
Ort, Verlag, Ausgabe: Bellingham : Society of Photo-Optical Instrumentation Engineers (SPIE)
Seiten: - Band / Heft: - Artikelnummer: 108650T Start- / Endseite: - Identifikator: -

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Titel: Proceedings of SPIE
Genre der Quelle: Reihe
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 10865 Artikelnummer: - Start- / Endseite: - Identifikator: -