Lymphatic Clearance from the Blood after Subarachnoid Hemorrhages

Semyachkina-Glushkovskaya, O.; Abdurashitov, A.; Dubrovsky, A.; Shirokov, A.; Navolokin, N.; Klimova, M.; Duarte Torres, E.; Khorovodov, A.; Mamedova, A.; Shareef, A. E.; Terskov, A.; Saranceva, E.; Iskra, T.; Kurths, Jürgen

doi:10.1117/12.2509065

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Lymphatic Clearance from the Blood after Subarachnoid Hemorrhages

Authors

Semyachkina-Glushkovskaya, O.
External Organizations;

Abdurashitov, A.
External Organizations;

Dubrovsky, A.
External Organizations;

Shirokov, A.
External Organizations;

Navolokin, N.
External Organizations;

Klimova, M.
External Organizations;

Duarte Torres, E.
External Organizations;

Khorovodov, A.
External Organizations;

Mamedova, A.
External Organizations;

Shareef, A. E.
External Organizations;

Terskov, A.
External Organizations;

Saranceva, E.
External Organizations;

Iskra, T.
External Organizations;

/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

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引用

Semyachkina-Glushkovskaya, O., Abdurashitov, A., Dubrovsky, A., Shirokov, A., Navolokin, N., Klimova, M., Duarte Torres, E., Khorovodov, A., Mamedova, A., Shareef, A. E., Terskov, A., Saranceva, E., Iskra, T., & Kurths, J. (2019). Lymphatic Clearance from the Blood after Subarachnoid Hemorrhages. In Q., Luo, J., Ding, & L., Fu (Eds.), Neural Imaging and Sensing 2019. Bellingham: Society of Photo-Optical Instrumentation Engineers (SPIE).

引用: https://publications.pik-potsdam.de/pubman/item/item_23861

要旨

Here we present preliminary experimental data suggesting about involvement of the meningeal and cervical lymphatics in neurorehabilitation. Using model of hemorrhagic stroke, immunohistochemical analysis and atomic absorption spectroscopy, we clearly demonstrate the lymphatic clearance from the blood after stroke via the meningeal lymphatic vessels with further accumulation of hemosiderin and iron (products of disaggregated hemoglobin) in the deep cervical node (dcLN). The optical coherent tomography (OCT) was used for in vivo monitoring of accumulation of gold nanorods (92 nm in diameter) in the dcLN after their injection into the cisterna magna with the aim of mimicking of the brain clearance from of blood. The both ex vivo and in vivo data show the lymphatic clearance from subjects (the blood/GNRs) injected into the subarachnoid space that might be an important mechanism of neurorehabilitation after the intracranial hemorrhages.