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  Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain

Semyachkina-Glushkovskaya, O., Sokolovski, S., Fedosov, I., Shirokov, A., Navolokin, N., Bucharskaya, A., Blokhina, I., Terskov, A., Dubrovski, A., Telnova, V., Tzven, A., Tzoy, M., Evsukova, A., Zhlatogosrkaya, D., Adushkina, V., Dmitrenko, A., Manzhaeva, M., Krupnova, V., Noghero, A., Bragin, D., Bragina, O., Borisova, E., Kurths, J., Rafailov, E. (2023): Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain. - International Journal of Molecular Sciences, 24, 18, 13696.
https://doi.org/10.3390/ijms241813696

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Semyachkina-Glushkovskaya, Oxana1, Author
Sokolovski, Sergey1, Author
Fedosov, Ivan1, Author
Shirokov, Alexander1, Author
Navolokin, Nikita1, Author
Bucharskaya, Alla1, Author
Blokhina, Inna1, Author
Terskov, Andrey1, Author
Dubrovski, Alexander1, Author
Telnova, Valeria1, Author
Tzven, Anna1, Author
Tzoy, Maria1, Author
Evsukova, Arina1, Author
Zhlatogosrkaya, Daria1, Author
Adushkina, Viktoria1, Author
Dmitrenko, Alexander1, Author
Manzhaeva, Maria1, Author
Krupnova, Valeria1, Author
Noghero, Alessio1, Author
Bragin, Denis1, Author
Bragina, Olga1, AuthorBorisova, Ekaterina1, AuthorKurths, Jürgen2, Author              Rafailov, Edik1, Author more..
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Abstract: Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the most lethal form of brain cancer, with very limited treatment options and a poor prognosis. In this study on rats, we demonstrate that glioblastoma (GBM) growth can be suppressed by photosensitizer-free laser treatment (PS-free-LT) using a quantum-dot-based 1267 nm laser diode. This wavelength, highly absorbed by oxygen, is capable of turning triplet oxygen to singlet form. Applying 1267 nm laser irradiation for a 4 week course with a total dose of 12.7 kJ/cm2 firmly suppresses GBM growth and increases survival rate from 34% to 64%, presumably via LT-activated apoptosis, inhibition of the proliferation of tumor cells, a reduction in intracranial pressure and stimulation of the lymphatic drainage and clearing functions. PS-free-LT is a promising breakthrough technology in non- or minimally invasive therapy for superficial GBMs in infants as well as in adult patients with high photosensitivity or an allergic reaction to PSs.

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Language(s): eng - English
 Dates: 2023-09-052023-09-05
 Publication Status: Finally published
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3390/ijms241813696
MDB-ID: No data to archive
PIKDOMAIN: RD4 - Complexity Science
Organisational keyword: RD4 - Complexity Science
Research topic keyword: Complex Networks
Research topic keyword: Nonlinear Dynamics
Research topic keyword: Health
Model / method: Nonlinear Data Analysis
OATYPE: Gold Open Access
 Degree: -

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Title: International Journal of Molecular Sciences
Source Genre: Journal, SCI, Scopus, oa
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Pages: - Volume / Issue: 24 (18) Sequence Number: 13696 Start / End Page: - Identifier: CoNE: https://publications.pik-potsdam.de/cone/journals/resource/international-journal-of-molecular-sciences
Publisher: MDPI