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  Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions

Semyachkina-Glushkovskaya, O., Abdurashitov, A., Dubrovsky, A., Klimova, M., Agranovich, I., Terskov, A., Shirokov, A., Vinnik, V., Kuzmina, A., Lezhnev, N., Blokhina, I., Shnitenkova, A., Tuchin, V., Rafailov, E., Kurths, J. (2020): Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions. - Biomedical Optics Express, 11, 2, 725-734.
https://doi.org/10.1364/BOE.383390

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Semyachkina-Glushkovskaya, Oxana1, Author
Abdurashitov, Arkady1, Author
Dubrovsky, Alexander1, Author
Klimova, Maria1, Author
Agranovich, Ilana1, Author
Terskov, Andrey1, Author
Shirokov, Alexander1, Author
Vinnik, Valeria1, Author
Kuzmina, Anna1, Author
Lezhnev, Nikita1, Author
Blokhina, Inna1, Author
Shnitenkova, Anastassia1, Author
Tuchin, Valery1, Author
Rafailov, Edik1, Author
Kurths, Jürgen2, Author              
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1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Abstract: There is a hypothesis that augmentation of the drainage and clearing function of the meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing neurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm) of lymphatic drainage and clearance. Our results obtained at optical coherence tomography (OCT) give strong evidence that low PBM doses (5 and 10 J/cm2) stimulate drainage function of the lymphatic vessels via vasodilation (OCT data on the mesenteric lymphatics) and stimulation of lymphatic clearance (OCT data on clearance of gold nanorods from the brain) that was supported by confocal imaging of clearance of FITC-dextran from the cortex via MLVs. We assume that PBM-mediated relaxation of the lymphatic vessels can be possible mechanisms underlying increasing the permeability of the lymphatic endothelium that allows molecules transported by the lymphatic vessels and explain PBM stimulation of lymphatic drainage and clearance. These findings open new strategies for the stimulation of MLVs functions and non-pharmacological therapy of brain diseases.

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 Dates: 2020-01-102020
 Publication Status: Finally published
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 Rev. Type: Peer
 Identifiers: DOI: 10.1364/BOE.383390
PIKDOMAIN: RD4 - Complexity Science
Organisational keyword: RD4 - Complexity Science
Research topic keyword: Health
MDB-ID: No data to archive
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Title: Biomedical Optics Express
Source Genre: Journal, SCI, Scopus, oa
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Pages: - Volume / Issue: 11 (2) Sequence Number: - Start / End Page: 725 - 734 Identifier: Publisher: PubMed Central
Other: 2156-7085
CoNE: https://publications.pik-potsdam.de/cone/journals/resource/biomedical-optics-express
Publisher: The Optical Society