Photobiomodulation of lymphatic drainage and clearance: perspective strategy 
for augmentation of meningeal lymphatic functions

Semyachkina-Glushkovskaya, Oxana; Abdurashitov, Arkady; Dubrovsky, Alexander; Klimova, Maria; Agranovich, Ilana; Terskov, Andrey; Shirokov, Alexander; Vinnik, Valeria; Kuzmina, Anna; Lezhnev, Nikita; Blokhina, Inna; Shnitenkova, Anastassia; Tuchin, Valery; Rafailov, Edik; Kurths, Jürgen

doi:10.1364/BOE.383390

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Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions

Urheber*innen

Semyachkina-Glushkovskaya, Oxana
External Organizations;

Abdurashitov, Arkady
External Organizations;

Dubrovsky, Alexander
External Organizations;

Klimova, Maria
External Organizations;

Agranovich, Ilana
External Organizations;

Terskov, Andrey
External Organizations;

Shirokov, Alexander
External Organizations;

Vinnik, Valeria
External Organizations;

Kuzmina, Anna
External Organizations;

Lezhnev, Nikita
External Organizations;

Blokhina, Inna
External Organizations;

Shnitenkova, Anastassia
External Organizations;

Tuchin, Valery
External Organizations;

Rafailov, Edik
External Organizations;

/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

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Zitation

Semyachkina-Glushkovskaya, O., Abdurashitov, A., Dubrovsky, A., Klimova, M., Agranovich, I., Terskov, A., Shirokov, A., Vinnik, V., Kuzmina, A., Lezhnev, N., Blokhina, I., Shnitenkova, A., Tuchin, V., Rafailov, E., Kurths, J. (2020): Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions. - Biomedical Optics Express, 11, 2, 725-734.
https://doi.org/10.1364/BOE.383390

Zitierlink: https://publications.pik-potsdam.de/pubman/item/item_25390

Zusammenfassung

There is a hypothesis that augmentation of the drainage and clearing function of the meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing neurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm) of lymphatic drainage and clearance. Our results obtained at optical coherence tomography (OCT) give strong evidence that low PBM doses (5 and 10 J/cm2) stimulate drainage function of the lymphatic vessels via vasodilation (OCT data on the mesenteric lymphatics) and stimulation of lymphatic clearance (OCT data on clearance of gold nanorods from the brain) that was supported by confocal imaging of clearance of FITC-dextran from the cortex via MLVs. We assume that PBM-mediated relaxation of the lymphatic vessels can be possible mechanisms underlying increasing the permeability of the lymphatic endothelium that allows molecules transported by the lymphatic vessels and explain PBM stimulation of lymphatic drainage and clearance. These findings open new strategies for the stimulation of MLVs functions and non-pharmacological therapy of brain diseases.