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  Technology of the photobiostimulation of the brain’s drainage system during sleep for improvement of learning and memory in male mice

Semyachkina-Glushkovskaya, O., Fedosov, I., Zaikin, A., Ageev, V., Ilyukov, E., Myagkov, D., Tuktarov, D., Blokhina, I., Shirokov, A., Terskov, A., Zlatogorskaya, D., Adushkina, V., Evsukova, A., Dubrovsky, A., Tsoy, M., Telnova, V., Manzhaeva, M., Dmitrenko, A., Krupnova, V., Kurths, J. (2024): Technology of the photobiostimulation of the brain’s drainage system during sleep for improvement of learning and memory in male mice. - Biomedical Optics Express, 15, 1, 44-58.
https://doi.org/10.1364/BOE.505618

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Semyachkina-Glushkovskaya, Oxana1, Autor
Fedosov, Ivan1, Autor
Zaikin, Alexey1, Autor
Ageev, Vasily1, Autor
Ilyukov, Egor1, Autor
Myagkov, Dmitry1, Autor
Tuktarov, Dmitry1, Autor
Blokhina, Inna1, Autor
Shirokov, Alexander1, Autor
Terskov, Andrey1, Autor
Zlatogorskaya, Daria1, Autor
Adushkina, Viktoria1, Autor
Evsukova, Arina1, Autor
Dubrovsky, Alexander1, Autor
Tsoy, Maria1, Autor
Telnova, Valeria1, Autor
Manzhaeva, Maria1, Autor
Dmitrenko, Alexander1, Autor
Krupnova, Valeria1, Autor
Kurths, Jürgen2, Autor              
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Zusammenfassung: In this study on healthy male mice using confocal imaging of dye spreading in the brain and its further accumulation in the peripheral lymphatics, we demonstrate stronger effects of photobiomodulation (PBM) on the brain’s drainage system in sleeping vs. awake animals. Using the Pavlovian instrumental transfer probe and the 2-objects-location test, we found that the 10-day course of PBM during sleep vs. wakefulness promotes improved learning and spatial memory in mice. For the first time, we present the technology for PBM under electroencephalographic (EEG) control that incorporates modern state of the art facilities of optoelectronics and biopotential detection and that can be built of relatively cheap and commercially available components. These findings open a new niche in the development of smart technologies for phototherapy of brain diseases during sleep.

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Sprache(n): eng - Englisch
 Datum: 2023-12-052024-01-01
 Publikationsstatus: Final veröffentlicht
 Seiten: 15
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1364/BOE.505618
MDB-ID: No data to archive
PIKDOMAIN: RD4 - Complexity Science
Organisational keyword: RD4 - Complexity Science
Research topic keyword: Health
Research topic keyword: Nonlinear Dynamics
Model / method: Nonlinear Data Analysis
OATYPE: Gold Open Access
 Art des Abschluß: -

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Titel: Biomedical Optics Express
Genre der Quelle: Zeitschrift, SCI, Scopus, oa
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 15 (1) Artikelnummer: - Start- / Endseite: 44 - 58 Identifikator: CoNE: https://publications.pik-potsdam.de/cone/journals/resource/biomedical-optics-express
Publisher: Optica Publishing Group