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  Cross-sectional study of health impairment related to post COVID-19 condition among participants of a large population-based cohort in Germany

Diexer, S., Frost, J., Ahnert, P., Baernighausen, T. W., Brenner, H., Fricke, J., Gabrysch, S., Greiser, K. H., Harth, V., Heise, J.-K., Kaaks, R., Karch, A., Keil, T., Klee, B., Klett-Tammen, C. J., Krist, L., Lampl, B. M. J., Leitzmann, M. F., Lieb, W., Meinke-Franze, C., Michels, K. B., Velásquez, I. M., Obi, N., Peters, A., Pfrommer, L. R., Pischon, T., Purschke, O., Rübsamen, N., Schikowski, T., Schmidt, B., Thierry, S., Völzke, H., Wright, M. N., Zeeb, H., Mikolajczyk, R. (2025): Cross-sectional study of health impairment related to post COVID-19 condition among participants of a large population-based cohort in Germany. - Scientific Reports, 15, 25830.
https://doi.org/10.1038/s41598-025-07894-7

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s41598-025-07894-7.pdf (Verlagsversion), 2MB
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 Urheber:
Diexer, Sophie1, Autor
Frost, Jonas1, Autor
Ahnert, Peter1, Autor
Baernighausen, Till W.1, Autor
Brenner, Hermann1, Autor
Fricke, Julia1, Autor
Gabrysch, Sabine2, Autor                 
Greiser, Karin Halina1, Autor
Harth, Volker1, Autor
Heise, Jana-Kristin1, Autor
Kaaks, Rudolf1, Autor
Karch, André1, Autor
Keil, Thomas1, Autor
Klee, Bianca1, Autor
Klett-Tammen, Carolina J.1, Autor
Krist, Lilian1, Autor
Lampl, Benedikt M. J.1, Autor
Leitzmann, Michael F.1, Autor
Lieb, Wolfgang1, Autor
Meinke-Franze, Claudia1, Autor
Michels, Karin B.1, AutorVelásquez, Ilais Moreno1, AutorObi, Nadia1, AutorPeters, Annette1, AutorPfrommer, Laura R.1, AutorPischon, Tobias1, AutorPurschke, Oliver1, AutorRübsamen, Nicole1, AutorSchikowski, Tamara1, AutorSchmidt, Börge1, AutorThierry, Sigrid1, AutorVölzke, Henry1, AutorWright, Marvin N1, AutorZeeb, Hajo1, AutorMikolajczyk, Rafael1, Autor mehr..
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Zusammenfassung: Post COVID-19 condition (PCC) is a substantial burden for patients, society, and the healthcare system. Participants of the German National Cohort (NAKO) were asked in an online survey about their self-perceived health, symptoms related to PCC, and infection status. PCC was defined as reporting symptoms for the time window 4–12 months after infection. Of 110,375 respondents (73% response), 86,833 were included in this analysis. Of these, 44,451 (51%) did not report a SARS-CoV-2 infection (no infection), 26,726 (31%) reported an infection but no symptoms 4–12 months after infection (infection/no PCC), and 15,656 (18%) reported an infection and symptoms (PCC). The median number of current symptoms at the time of the survey was two for the "no infection" and the "infection/no PCC" group, and five for the "PCC" group. Participants with PCC had a substantially higher probability of having worse self-perceived health (OR 1.84, 95% CI [1.75; 1.93] compared to the "no infection" group, adjusting for sex, age, education and chronic diseases with elevated risk for developing PCC. After adjusting for the number of current symptoms related to PCC, this difference disappeared, suggesting that the symptoms collected explain the impairment of self-perceived health in the PCC group.

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Sprache(n): eng - English
 Datum: 2024-10-072025-06-182025-07-162025-07-16
 Publikationsstatus: Final veröffentlicht
 Seiten: 9
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/s41598-025-07894-7
Organisational keyword: RD2 - Climate Resilience
PIKDOMAIN: RD2 - Climate Resilience
MDB-ID: No data to archive
Working Group: Climate Change and Health
Research topic keyword: Health
Regional keyword: Europe
Model / method: Quantitative Methods
OATYPE: Gold Open Access
 Art des Abschluß: -

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Titel: Scientific Reports
Genre der Quelle: Zeitschrift, SCI, Scopus, p3, OA
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 15 Artikelnummer: 25830 Start- / Endseite: - Identifikator: CoNE: https://publications.pik-potsdam.de/cone/journals/resource/journals2_395
Publisher: Nature