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  An algebraic generalisation of the Krankheit-Operator modelling neurological disorders

Mannone, M., Mach, T. (2026 online): An algebraic generalisation of the Krankheit-Operator modelling neurological disorders. - European Physical Journal - Special Topics.
https://doi.org/10.1140/epjs/s11734-025-02099-5

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 Creators:
Mannone, Maria1, Author           
Mach, Thomas2, Author
Affiliations:
1Potsdam Institute for Climate Impact Research, ou_persistent13              
2External Organizations, ou_persistent22              

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 Abstract: Several neurological disorders can be described as alterations of the brain connectome, both anatomic and functional. To model diseases and compare them, it has been proposed the Krankheit-operator (K-operator), which acts on the weights of the connectome, reproducing the effects of specific disorders. In this article, with algebraic tools, we attempt to provide a more general definition of the operator, that encompasses the previous different definitions provided. We consider a general setting where the linear operator is an endomorphism on the vector space of n × n matrices. We show that the left and right matrix multiplication and a Hadamard multiplications can all be described as a special structured operator.

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Language(s): eng - English
 Dates: 2025-12-012026-02-04
 Publication Status: Published online
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: MDB-ID: No data to archive
PIKDOMAIN: RD4 - Complexity Science
Organisational keyword: RD4 - Complexity Science
Working Group: Development of advanced time series analysis techniques
OATYPE: Hybrid Open Access
DOI: 10.1140/epjs/s11734-025-02099-5
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Title: European Physical Journal - Special Topics
Source Genre: Journal, SCI, Scopus, p3
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: CoNE: https://publications.pik-potsdam.de/cone/journals/resource/150617
Publisher: Springer