Photodynamic Opening of the Blood–Brain Barrier and the Meningeal Lymphatic 
System: The New Niche in Immunotherapy for Brain Tumors

Semyachkina-Glushkovskaya, Oxana; Terskov, Andrey; Khorovodov, Alexander; Telnova, Valeria; Blokhina, Inna; Saranceva, Elena; Kurths, Jürgen

doi:10.3390/pharmaceutics14122612

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Photodynamic Opening of the Blood–Brain Barrier and the Meningeal Lymphatic System: The New Niche in Immunotherapy for Brain Tumors

Authors

Semyachkina-Glushkovskaya, Oxana
External Organizations;

Terskov, Andrey
External Organizations;

Khorovodov, Alexander
External Organizations;

Telnova, Valeria
External Organizations;

Blokhina, Inna
External Organizations;

Saranceva, Elena
External Organizations;

/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

URL

There are no locators available

フルテキスト (公開)

semyachkina_2022_pharmaceutics-14-02612-v2.pdf
(出版社版), 5MB

付随資料 (公開)

There is no public supplementary material available

引用

Semyachkina-Glushkovskaya, O., Terskov, A., Khorovodov, A., Telnova, V., Blokhina, I., Saranceva, E., & Kurths, J. (2022). Photodynamic Opening of the Blood–Brain Barrier and the Meningeal Lymphatic System: The New Niche in Immunotherapy for Brain Tumors. Pharmaceutics, 14(12):. doi:10.3390/pharmaceutics14122612.

引用: https://publications.pik-potsdam.de/pubman/item/item_27962

要旨

Photodynamic therapy (PDT) is a promising add-on therapy to the current standard of care for patients with glioblastoma (GBM). The traditional explanation of the anti-cancer PDT effects involves the PDT-induced generation of a singlet oxygen in the GBM cells, which causes tumor cell death and microvasculature collapse. Recently, new vascular mechanisms of PDT associated with opening of the blood–brain barrier (OBBB) and the activation of functions of the meningeal lymphatic vessels have been discovered. In this review, we highlight the emerging trends and future promises of immunotherapy for brain tumors and discuss PDT-OBBB as a new niche and an important informative platform for the development of innovative pharmacological strategies for the modulation of brain tumor immunity and the improvement of immunotherapy for GBM.