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Book Chapter

Photomodulation of Lymphatic Delivery of Bevacizumab to the Brain: The Role of Singlet Oxygen


Semyachkina-Glushkovskaya,  Oxana
External Organizations;

Diduk,  Sergey
External Organizations;

Anna,  Eroshova
External Organizations;

Elina,  Dosadina
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Artem,  Kruglov
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Khorovodov,  Alexander
External Organizations;

Shirokov,  Alexander
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Fedosov,  Ivan
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Dubrovsky,  Alexander
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Blokhina,  Inna
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Terskov,  Andrey
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Karandin,  Georgy
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Evsukova,  Arina
External Organizations;

Tsven,  Anna
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Telnova,  Valeria
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Afranovich,  Ilana
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Sokolovski,  Sergey
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Rafailov,  Edik
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Kurths,  Jürgen
Potsdam Institute for Climate Impact Research;

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Semyachkina-Glushkovskaya, O., Diduk, S., Anna, E., Elina, D., Artem, K., Khorovodov, A., Shirokov, A., Fedosov, I., Dubrovsky, A., Blokhina, I., Terskov, A., Karandin, G., Evsukova, A., Tsven, A., Telnova, V., Afranovich, I., Sokolovski, S., Rafailov, E., Kurths, J. (2022): Photomodulation of Lymphatic Delivery of Bevacizumab to the Brain: The Role of Singlet Oxygen. - In: Scholkmann, F., LaManna, J., Wolf, U. (Eds.), Oxygen Transport to Tissue XLIII, (Advances in Experimental Medicine and Biology ; 1395), Cham : Springer, 53-57.

Cite as: https://publications.pik-potsdam.de/pubman/item/item_27966
The blood-brain barrier (BBB) poses a significant challenge for drug delivery to the brain. Therefore, the development of safe methods for an effective delivery of medications to the brain can be a revolutionary step in overcoming this limitation. Using a quantum-dot-based 1267 nm laser (photosensitiser-free generation of singlet oxygen), we clearly show the photostimulation of lymphatic delivery of bevacizumab (BMZ) to the brain tissues and the meninges. These pilot findings open promising perspectives for photomodulation of a lymphatic brain drug delivery bypassing the BBB, and potentially enabling a breakthrough strategy in therapy of glioma using BMZ and other chemotherapy drugs.