Deutsch
 
Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Low-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma

Urheber*innen

Semyachkina-Glushkovskaya,  Oxana
External Organizations;

Bragin,  Denis
External Organizations;

Bragina,  Olga
External Organizations;

Socolovski,  Sergey
External Organizations;

Shirokov,  Alexander
External Organizations;

Fedosov,  Ivan
External Organizations;

Ageev,  Vasily
External Organizations;

Blokhina,  Inna
External Organizations;

Dubrovsky,  Alexander
External Organizations;

Telnova,  Valeria
External Organizations;

Terskov,  Andrey
External Organizations;

Khorovodov,  Alexander
External Organizations;

Elovenko,  Daria
External Organizations;

Evsukova,  Arina
External Organizations;

Zhoy,  Maria
External Organizations;

Agranovich,  Ilana
External Organizations;

Vodovozova,  Elena
External Organizations;

Alekseeva,  Anna
External Organizations;

/persons/resource/Juergen.Kurths

Kurths,  Jürgen
Potsdam Institute for Climate Impact Research;

Rafailov,  Edik
External Organizations;

Externe Ressourcen
Es sind keine externen Ressourcen hinterlegt
Volltexte (frei zugänglich)
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Semyachkina-Glushkovskaya, O., Bragin, D., Bragina, O., Socolovski, S., Shirokov, A., Fedosov, I., Ageev, V., Blokhina, I., Dubrovsky, A., Telnova, V., Terskov, A., Khorovodov, A., Elovenko, D., Evsukova, A., Zhoy, M., Agranovich, I., Vodovozova, E., Alekseeva, A., Kurths, J., Rafailov, E. (2023): Low-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma. - Pharmaceutics, 15, 2, 567.
https://doi.org/10.3390/pharmaceutics15020567


Zitierlink: https://publications.pik-potsdam.de/pubman/item/item_28296
Zusammenfassung
The progress in brain diseases treatment is limited by the blood-brain barrier (BBB), which prevents delivery of the vast majority of drugs from the blood into the brain. In this study, we discover unknown phenomenon of opening of the BBBB (BBBO) by low-level laser treatment (LLLT, 1268 nm) in the mouse cortex. LLLT-BBBO is accompanied by activation of the brain drainage system contributing effective delivery of liposomes into glioblastoma (GBM). The LLLT induces the generation of singlet oxygen without photosensitizers (PSs) in the blood endothelial cells and astrocytes, which can be a trigger mechanism of BBBO. LLLT-BBBO causes activation of the ABC-transport system with a temporal decrease in the expression of tight junction proteins. The BBB recovery is accompanied by activation of neuronal metabolic activity and stabilization of the BBB permeability. LLLT-BBBO can be used as a new opportunity of interstitial PS-free photodynamic therapy (PDT) for modulation of brain tumor immunity and improvement of immuno-therapy for GBM in infants in whom PDT with PSs, radio- and chemotherapy are strongly limited, as well as in adults with a high allergic reaction to PSs.