Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain

Semyachkina-Glushkovskaya, Oxana; Sokolovski, Sergey; Fedosov, Ivan; Shirokov, Alexander; Navolokin, Nikita; Bucharskaya, Alla; Blokhina, Inna; Terskov, Andrey; Dubrovski, Alexander; Telnova, Valeria; Tzven, Anna; Tzoy, Maria; Evsukova, Arina; Zhlatogosrkaya, Daria; Adushkina, Viktoria; Dmitrenko, Alexander; Manzhaeva, Maria; Krupnova, Valeria; Noghero, Alessio; Bragin, Denis; Bragina, Olga; Borisova, Ekaterina; Kurths, Jürgen; Rafailov, Edik

doi:10.3390/ijms241813696

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Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain

Authors

Semyachkina-Glushkovskaya, Oxana
External Organizations;

Sokolovski, Sergey
External Organizations;

Fedosov, Ivan
External Organizations;

Shirokov, Alexander
External Organizations;

Navolokin, Nikita
External Organizations;

Bucharskaya, Alla
External Organizations;

Blokhina, Inna
External Organizations;

Terskov, Andrey
External Organizations;

Dubrovski, Alexander
External Organizations;

Telnova, Valeria
External Organizations;

Tzven, Anna
External Organizations;

Tzoy, Maria
External Organizations;

Evsukova, Arina
External Organizations;

Zhlatogosrkaya, Daria
External Organizations;

Adushkina, Viktoria
External Organizations;

Dmitrenko, Alexander
External Organizations;

Manzhaeva, Maria
External Organizations;

Krupnova, Valeria
External Organizations;

Noghero, Alessio
External Organizations;

Bragin, Denis
External Organizations;

Bragina, Olga
External Organizations;

Borisova, Ekaterina
External Organizations;

/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

Rafailov, Edik
External Organizations;

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Semyachkina_2023_ijms-24-13696.pdf
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Citation

Semyachkina-Glushkovskaya, O., Sokolovski, S., Fedosov, I., Shirokov, A., Navolokin, N., Bucharskaya, A., Blokhina, I., Terskov, A., Dubrovski, A., Telnova, V., Tzven, A., Tzoy, M., Evsukova, A., Zhlatogosrkaya, D., Adushkina, V., Dmitrenko, A., Manzhaeva, M., Krupnova, V., Noghero, A., Bragin, D., Bragina, O., Borisova, E., Kurths, J., Rafailov, E. (2023): Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain. - International Journal of Molecular Sciences, 24, 18, 13696.
https://doi.org/10.3390/ijms241813696

Cite as: https://publications.pik-potsdam.de/pubman/item/item_28935

Abstract

Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the most lethal form of brain cancer, with very limited treatment options and a poor prognosis. In this study on rats, we demonstrate that glioblastoma (GBM) growth can be suppressed by photosensitizer-free laser treatment (PS-free-LT) using a quantum-dot-based 1267 nm laser diode. This wavelength, highly absorbed by oxygen, is capable of turning triplet oxygen to singlet form. Applying 1267 nm laser irradiation for a 4 week course with a total dose of 12.7 kJ/cm2 firmly suppresses GBM growth and increases survival rate from 34% to 64%, presumably via LT-activated apoptosis, inhibition of the proliferation of tumor cells, a reduction in intracranial pressure and stimulation of the lymphatic drainage and clearing functions. PS-free-LT is a promising breakthrough technology in non- or minimally invasive therapy for superficial GBMs in infants as well as in adult patients with high photosensitivity or an allergic reaction to PSs.