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Journal Article

Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage


Li,  Dongyu
External Organizations;

Liu,  Shaojun
External Organizations;

Yu,  Tingting
External Organizations;

Liu,  Zhang
External Organizations;

Sun,  Silin
External Organizations;

Bragin,  Denis
External Organizations;

Shirokov,  Alexander
External Organizations;

Navolokin,  Nikita
External Organizations;

Bragina,  Olga
External Organizations;

Hu,  Zhengwu
External Organizations;


Kurths,  Jürgen
Potsdam Institute for Climate Impact Research;

Fedosov,  Ivan
External Organizations;

Blokhina,  Inna
External Organizations;

Dubrovski,  Alexander
External Organizations;

Khorovodov,  Alexander
External Organizations;

Terskov,  Andrey
External Organizations;

Tzoy,  Maria
External Organizations;

Semyachkina-Glushkovskaya,  Oxana
External Organizations;

Zhu,  Dan
External Organizations;

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Li, D., Liu, S., Yu, T., Liu, Z., Sun, S., Bragin, D., Shirokov, A., Navolokin, N., Bragina, O., Hu, Z., Kurths, J., Fedosov, I., Blokhina, I., Dubrovski, A., Khorovodov, A., Terskov, A., Tzoy, M., Semyachkina-Glushkovskaya, O., Zhu, D. (2023): Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage. - Nature Communications, 14, 6104.

Cite as: https://publications.pik-potsdam.de/pubman/item/item_29121
Intraventricular hemorrhage is one of the most fatal forms of brain injury that is a common complication of premature infants. However, the therapy of this type of hemorrhage is limited, and new strategies are needed to reduce hematoma expansion. Here we show that the meningeal lymphatics is a pathway to remove red blood cells from the brain’s ventricular system of male human, adult and newborn rodents and is a target for non-invasive transcranial near infrared photobiomodulation. Our results uncover the clinical significance of phototherapy of intraventricular hemorrhage in 4-day old male rat pups that have the brain similar to a preterm human brain. The course of phototherapy in newborn rats provides fast recovery after intraventricular hemorrhage due to photo-improvements of lymphatic drainage and clearing functions. These findings shed light on the mechanisms of phototherapy of intraventricular hemorrhage that can be a clinically relevant technology for treatment of neonatal intracerebral bleedings.