Technology of the photobiostimulation of the brain’s drainage system during 
sleep for improvement of learning and memory in male mice

Semyachkina-Glushkovskaya, Oxana; Fedosov, Ivan; Zaikin, Alexey; Ageev, Vasily; Ilyukov, Egor; Myagkov, Dmitry; Tuktarov, Dmitry; Blokhina, Inna; Shirokov, Alexander; Terskov, Andrey; Zlatogorskaya, Daria; Adushkina, Viktoria; Evsukova, Arina; Dubrovsky, Alexander; Tsoy, Maria; Telnova, Valeria; Manzhaeva, Maria; Dmitrenko, Alexander; Krupnova, Valeria; Kurths, Jürgen

doi:10.1364/BOE.505618

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Technology of the photobiostimulation of the brain’s drainage system during sleep for improvement of learning and memory in male mice

Authors

Semyachkina-Glushkovskaya, Oxana
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Fedosov, Ivan
External Organizations;

Zaikin, Alexey
External Organizations;

Ageev, Vasily
External Organizations;

Ilyukov, Egor
External Organizations;

Myagkov, Dmitry
External Organizations;

Tuktarov, Dmitry
External Organizations;

Blokhina, Inna
External Organizations;

Shirokov, Alexander
External Organizations;

Terskov, Andrey
External Organizations;

Zlatogorskaya, Daria
External Organizations;

Adushkina, Viktoria
External Organizations;

Evsukova, Arina
External Organizations;

Dubrovsky, Alexander
External Organizations;

Tsoy, Maria
External Organizations;

Telnova, Valeria
External Organizations;

Manzhaeva, Maria
External Organizations;

Dmitrenko, Alexander
External Organizations;

Krupnova, Valeria
External Organizations;

/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

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semyachkina_2024_boe-15-1-44.pdf
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Citation

Semyachkina-Glushkovskaya, O., Fedosov, I., Zaikin, A., Ageev, V., Ilyukov, E., Myagkov, D., Tuktarov, D., Blokhina, I., Shirokov, A., Terskov, A., Zlatogorskaya, D., Adushkina, V., Evsukova, A., Dubrovsky, A., Tsoy, M., Telnova, V., Manzhaeva, M., Dmitrenko, A., Krupnova, V., Kurths, J. (2024): Technology of the photobiostimulation of the brain’s drainage system during sleep for improvement of learning and memory in male mice. - Biomedical Optics Express, 15, 1, 44-58.
https://doi.org/10.1364/BOE.505618

Cite as: https://publications.pik-potsdam.de/pubman/item/item_30773

Abstract

In this study on healthy male mice using confocal imaging of dye spreading in the brain and its further accumulation in the peripheral lymphatics, we demonstrate stronger effects of photobiomodulation (PBM) on the brain’s drainage system in sleeping vs. awake animals. Using the Pavlovian instrumental transfer probe and the 2-objects-location test, we found that the 10-day course of PBM during sleep vs. wakefulness promotes improved learning and spatial memory in mice. For the first time, we present the technology for PBM under electroencephalographic (EEG) control that incorporates modern state of the art facilities of optoelectronics and biopotential detection and that can be built of relatively cheap and commercially available components. These findings open a new niche in the development of smart technologies for phototherapy of brain diseases during sleep.