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Cross-sectional study of health impairment related to post COVID-19 condition among participants of a large population-based cohort in Germany

Urheber*innen

Diexer,  Sophie
External Organizations;

Frost,  Jonas
External Organizations;

Ahnert,  Peter
External Organizations;

Baernighausen,  Till W.
External Organizations;

Brenner,  Hermann
External Organizations;

Fricke,  Julia
External Organizations;

/persons/resource/gabrysch

Gabrysch,  Sabine       
Potsdam Institute for Climate Impact Research;

Greiser,  Karin Halina
External Organizations;

Harth,  Volker
External Organizations;

Heise,  Jana-Kristin
External Organizations;

Kaaks,  Rudolf
External Organizations;

Karch,  André
External Organizations;

Keil,  Thomas
External Organizations;

Klee,  Bianca
External Organizations;

Klett-Tammen,  Carolina J.
External Organizations;

Krist,  Lilian
External Organizations;

Lampl,  Benedikt M. J.
External Organizations;

Leitzmann,  Michael F.
External Organizations;

Lieb,  Wolfgang
External Organizations;

Meinke-Franze,  Claudia
External Organizations;

Michels,  Karin B.
External Organizations;

Velásquez,  Ilais Moreno
External Organizations;

Obi,  Nadia
External Organizations;

Peters,  Annette
External Organizations;

Pfrommer,  Laura R.
External Organizations;

Pischon,  Tobias
External Organizations;

Purschke,  Oliver
External Organizations;

Rübsamen,  Nicole
External Organizations;

Schikowski,  Tamara
External Organizations;

Schmidt,  Börge
External Organizations;

Thierry,  Sigrid
External Organizations;

Völzke,  Henry
External Organizations;

Wright,  Marvin N
External Organizations;

Zeeb,  Hajo
External Organizations;

Mikolajczyk,  Rafael
External Organizations;

Externe Ressourcen
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Volltexte (beschränkter Zugriff)
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Volltexte (frei zugänglich)

s41598-025-07894-7.pdf
(Verlagsversion), 2MB

Ergänzendes Material (frei zugänglich)
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Zitation

Diexer, S., Frost, J., Ahnert, P., Baernighausen, T. W., Brenner, H., Fricke, J., Gabrysch, S., Greiser, K. H., Harth, V., Heise, J.-K., Kaaks, R., Karch, A., Keil, T., Klee, B., Klett-Tammen, C. J., Krist, L., Lampl, B. M. J., Leitzmann, M. F., Lieb, W., Meinke-Franze, C., Michels, K. B., Velásquez, I. M., Obi, N., Peters, A., Pfrommer, L. R., Pischon, T., Purschke, O., Rübsamen, N., Schikowski, T., Schmidt, B., Thierry, S., Völzke, H., Wright, M. N., Zeeb, H., Mikolajczyk, R. (2025): Cross-sectional study of health impairment related to post COVID-19 condition among participants of a large population-based cohort in Germany. - Scientific Reports, 15, 25830.
https://doi.org/10.1038/s41598-025-07894-7


Zitierlink: https://publications.pik-potsdam.de/pubman/item/item_32552
Zusammenfassung
Post COVID-19 condition (PCC) is a substantial burden for patients, society, and the healthcare system. Participants of the German National Cohort (NAKO) were asked in an online survey about their self-perceived health, symptoms related to PCC, and infection status. PCC was defined as reporting symptoms for the time window 4–12 months after infection. Of 110,375 respondents (73% response), 86,833 were included in this analysis. Of these, 44,451 (51%) did not report a SARS-CoV-2 infection (no infection), 26,726 (31%) reported an infection but no symptoms 4–12 months after infection (infection/no PCC), and 15,656 (18%) reported an infection and symptoms (PCC). The median number of current symptoms at the time of the survey was two for the "no infection" and the "infection/no PCC" group, and five for the "PCC" group. Participants with PCC had a substantially higher probability of having worse self-perceived health (OR 1.84, 95% CI [1.75; 1.93] compared to the "no infection" group, adjusting for sex, age, education and chronic diseases with elevated risk for developing PCC. After adjusting for the number of current symptoms related to PCC, this difference disappeared, suggesting that the symptoms collected explain the impairment of self-perceived health in the PCC group.