Increased cardiorespiratory coordination in preeclampsia

Berg, K.; Kraemer, J. F.; Riedl, Maik; Stepan, H.; Kurths, Jürgen; Wessel, N.

doi:10.1088/1361-6579/aa64b0

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Increased cardiorespiratory coordination in preeclampsia

Authors

Berg, K.
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Kraemer, J. F.
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/persons/resource/maik.riedl

Riedl, Maik
Potsdam Institute for Climate Impact Research;

Stepan, H.
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Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

Wessel, N.
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引用

Berg, K., Kraemer, J. F., Riedl, M., Stepan, H., Kurths, J., & Wessel, N. (2017). Increased cardiorespiratory coordination in preeclampsia. Physiological Measurement, 38(5), 912-924. doi:10.1088/1361-6579/aa64b0.

引用: https://publications.pik-potsdam.de/pubman/item/item_21727

要旨

Preeclampsia is one of the main sources of morbidity in pregnancy with a high mortality rate without a known ultimate cause. Using a corpus including 927 measurements of pregnant women with and without different hypertonic diseases at multiple stages of pregnancy, we utilised a new approach to analyse cardiorespiratory coordination. Since the recording quality of respiratory effort was limited due to a high signal to noise ratio, we applied an ECG derived respiration approach to create an ersatz respiratory signal. After applying the few available recordings with a sufficiently high quality of the respiratory signal to validate the substitute, coordigrams were calculated and quantified by utilising an epsilon method. We showed significant (p < 0.05) differences in the coordination in a matched (BMI, age, gestational week) comparison of preeclamptic and healthy subjects. Hopefully future applications of and improvements on these methods are able to create a fast and convenient prediction methodology to reduce the impact of this disease as well as help in the determination of its underlying cause.