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Journal Article

Brain Mechanisms of COVID-19-Sleep Disorders

Authors

Semyachkina-Glushkovskaya,  Oxana
External Organizations;

Mamedova,  Aysel
External Organizations;

Vinnik,  Valeria
External Organizations;

Klimova,  Maria
External Organizations;

Saranceva,  Elena
External Organizations;

Ageev,  Vasily
External Organizations;

Yu,  Tingting
External Organizations;

Zhu,  Dan
External Organizations;

Penzel,  Thomas
External Organizations;

/persons/resource/Juergen.Kurths

Kurths,  Jürgen
Potsdam Institute for Climate Impact Research;

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Fulltext (public)

semyachkina_ijms-22-06917.pdf
(Publisher version), 2MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Semyachkina-Glushkovskaya, O., Mamedova, A., Vinnik, V., Klimova, M., Saranceva, E., Ageev, V., Yu, T., Zhu, D., Penzel, T., Kurths, J. (2021): Brain Mechanisms of COVID-19-Sleep Disorders. - International Journal of Molecular Sciences, 22, 13, 6917.
https://doi.org/10.3390/ijms22136917


Cite as: https://publications.pik-potsdam.de/pubman/item/item_26422
Abstract
2020 and 2021 have been unprecedented years due to the rapid spread of the modified severe acute respiratory syndrome coronavirus around the world. The coronavirus disease 2019 (COVID-19) causes atypical infiltrated pneumonia with many neurological symptoms, and major sleep changes. The exposure of people to stress, such as social confinement and changes in daily routines, is accompanied by various sleep disturbances, known as ‘coronasomnia’ phenomenon. Sleep disorders induce neuroinflammation, which promotes the blood–brain barrier (BBB) disruption and entry of antigens and inflammatory factors into the brain. Here, we review findings and trends in sleep research in 2020–2021, demonstrating how COVID-19 and sleep disorders can induce BBB leakage via neuroinflammation, which might contribute to the ‘coronasomnia’ phenomenon. The new studies suggest that the control of sleep hygiene and quality should be incorporated into the rehabilitation of COVID-19 patients. We also discuss perspective strategies for the prevention of COVID-19-related BBB disorders. We demonstrate that sleep might be a novel biomarker of BBB leakage, and the analysis of sleep EEG patterns can be a breakthrough non-invasive technology for diagnosis of the COVID-19-caused BBB disruption.