Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New 
Strategies in Preventing Alzheimer’s Disease

Semyachkina-Glushkovskaya, Oxana; Penzel, Thomas; Blokhina, Inna; Khorovodov, Alexander; Fedosov, Ivan; Yu, Tingting; Karandin, Georgy; Evsukova, Arina; Elovenko, Dariya; Adushkina, Viktoria; Shirokov, Alexander; Dubrovskii, Alexander; Terskov, Andrey; Navolokin, Nikita; Tzoy, Maria; Ageev, Vasily; Agranovich, Ilana; Telnova, Valeria; Tsven, Anna; Kurths, Jürgen

doi:10.3390/cells10123289

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学術論文

Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer’s Disease

Authors

Semyachkina-Glushkovskaya, Oxana
External Organizations;

Penzel, Thomas
External Organizations;

Blokhina, Inna
External Organizations;

Khorovodov, Alexander
External Organizations;

Fedosov, Ivan
External Organizations;

Yu, Tingting
External Organizations;

Karandin, Georgy
External Organizations;

Evsukova, Arina
External Organizations;

Elovenko, Dariya
External Organizations;

Adushkina, Viktoria
External Organizations;

Shirokov, Alexander
External Organizations;

Dubrovskii, Alexander
External Organizations;

Terskov, Andrey
External Organizations;

Navolokin, Nikita
External Organizations;

Tzoy, Maria
External Organizations;

Ageev, Vasily
External Organizations;

Agranovich, Ilana
External Organizations;

Telnova, Valeria
External Organizations;

Tsven, Anna
External Organizations;

/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

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27050oa.pdf
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引用

Semyachkina-Glushkovskaya, O., Penzel, T., Blokhina, I., Khorovodov, A., Fedosov, I., Yu, T., Karandin, G., Evsukova, A., Elovenko, D., Adushkina, V., Shirokov, A., Dubrovskii, A., Terskov, A., Navolokin, N., Tzoy, M., Ageev, V., Agranovich, I., Telnova, V., Tsven, A., & Kurths, J. (2021). Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer’s Disease. Cells, 10(12):. doi:10.3390/cells10123289.

引用: https://publications.pik-potsdam.de/pubman/item/item_27050

要旨

The deposition of amyloid-β (Aβ) in the brain is a risk factor for Alzheimer’s disease (AD). Therefore, new strategies for the stimulation of Aβ clearance from the brain can be useful in preventing AD. Transcranial photostimulation (PS) is considered a promising method for AD therapy. In our previous studies, we clearly demonstrated the PS-mediated stimulation of lymphatic clearing functions, including Aβ removal from the brain. There is increasing evidence that sleep plays an important role in Aβ clearance. Here, we tested our hypothesis that PS at night can stimulate Aβ clearance from the brain more effectively than PS during the day. Our results on healthy mice show that Aβ clearance from the brain occurs faster at night than during wakefulness. The PS course at night improves memory and reduces Aβ accumulation in the brain of AD mice more effectively than the PS course during the day. Our results suggest that night PS is a more promising candidate as an effective method in preventing AD than daytime PS. These data are an important informative platform for the development of new noninvasive and nonpharmacological technologies for AD therapy as well as for preventing Aβ accumulation in the brain of people with disorder of Aβ metabolism, sleep deficit, elderly age, and jet lag.