Photomodulation of Lymphatic Delivery of Bevacizumab to the Brain: The Role of 
Singlet Oxygen

Semyachkina-Glushkovskaya, Oxana; Diduk, Sergey; Anna, Eroshova; Elina, Dosadina; Artem, Kruglov; Khorovodov, Alexander; Shirokov, Alexander; Fedosov, Ivan; Dubrovsky, Alexander; Blokhina, Inna; Terskov, Andrey; Karandin, Georgy; Evsukova, Arina; Tsven, Anna; Telnova, Valeria; Afranovich, Ilana; Sokolovski, Sergey; Rafailov, Edik; Kurths, Jürgen

doi:10.1007/978-3-031-14190-4_9

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Photomodulation of Lymphatic Delivery of Bevacizumab to the Brain: The Role of Singlet Oxygen

Authors

Semyachkina-Glushkovskaya, Oxana
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Diduk, Sergey
External Organizations;

Anna, Eroshova
External Organizations;

Elina, Dosadina
External Organizations;

Artem, Kruglov
External Organizations;

Khorovodov, Alexander
External Organizations;

Shirokov, Alexander
External Organizations;

Fedosov, Ivan
External Organizations;

Dubrovsky, Alexander
External Organizations;

Blokhina, Inna
External Organizations;

Terskov, Andrey
External Organizations;

Karandin, Georgy
External Organizations;

Evsukova, Arina
External Organizations;

Tsven, Anna
External Organizations;

Telnova, Valeria
External Organizations;

Afranovich, Ilana
External Organizations;

Sokolovski, Sergey
External Organizations;

Rafailov, Edik
External Organizations;

/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

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Citation

Semyachkina-Glushkovskaya, O., Diduk, S., Anna, E., Elina, D., Artem, K., Khorovodov, A., Shirokov, A., Fedosov, I., Dubrovsky, A., Blokhina, I., Terskov, A., Karandin, G., Evsukova, A., Tsven, A., Telnova, V., Afranovich, I., Sokolovski, S., Rafailov, E., Kurths, J. (2022): Photomodulation of Lymphatic Delivery of Bevacizumab to the Brain: The Role of Singlet Oxygen. - In: Scholkmann, F., LaManna, J., Wolf, U. (Eds.), Oxygen Transport to Tissue XLIII, (Advances in Experimental Medicine and Biology ; 1395), Cham : Springer, 53-57.
https://doi.org/10.1007/978-3-031-14190-4_9

Cite as: https://publications.pik-potsdam.de/pubman/item/item_27966

Abstract

The blood-brain barrier (BBB) poses a significant challenge for drug delivery to the brain. Therefore, the development of safe methods for an effective delivery of medications to the brain can be a revolutionary step in overcoming this limitation. Using a quantum-dot-based 1267 nm laser (photosensitiser-free generation of singlet oxygen), we clearly show the photostimulation of lymphatic delivery of bevacizumab (BMZ) to the brain tissues and the meninges. These pilot findings open promising perspectives for photomodulation of a lymphatic brain drug delivery bypassing the BBB, and potentially enabling a breakthrough strategy in therapy of glioma using BMZ and other chemotherapy drugs.