Exploring chronomodulated radiotherapy strategies in a chaotic population model

Ramírez-Ávila, Gonzalo Marcelo; Kurths, Jürgen; Gonze, Didier; Dupont, Geneviève

doi:10.1016/j.chaos.2023.113743

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Exploring chronomodulated radiotherapy strategies in a chaotic population model

Authors

Ramírez-Ávila, Gonzalo Marcelo
External Organizations;

/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

Gonze, Didier
External Organizations;

Dupont, Geneviève
External Organizations;

URL

There are no locators available

フルテキスト (公開)

There are no public fulltexts stored in PIKpublic

付随資料 (公開)

There is no public supplementary material available

引用

Ramírez-Ávila, G. M., Kurths, J., Gonze, D., & Dupont, G. (2023). Exploring chronomodulated radiotherapy strategies in a chaotic population model. Chaos, Solitons and Fractals, 173:. doi:10.1016/j.chaos.2023.113743.

引用: https://publications.pik-potsdam.de/pubman/item/item_28953

要旨

We present a simple nonlinear model describing the population dynamics of cancerous, healthy, and effector cells submitted to ionizing radiation. We examine the situations in which intermittently high doses of radiation affect the cells as it occurs in radiotherapy. We characterize the effect of various irradiation parameters, such as the total delivered dose for a given standard dose rate and the number of treatment sessions seeking situations that optimize normal cells survival. In other words, we are interested in enhancing the effectiveness of a radiotherapy treatment by adjusting the temporal pattern of the dose deliverance through an exhaustive dynamical characterization of the system. This includes the study of the parameter planes, the populations’ dynamical behavior going from fixed points to chaotic oscillations, and the basins of attraction. This work leads to counter-intuitive predictions and constitutes a step towards a model of chronomodulated radiotherapy.