Mechanisms of Photostimulation of Brain's Waste Disposal System: The Role of 
Singlet Oxygen

Semyachkina-Glushkovskaya, Oxana; Bragin, Denis; Fedosov, Ivan; Blokhina, Inna; Khorovodov, Alexander; Terskov, Andrey; Shirokov, Alexander; Dubrovsky, Alexander; Vinnik, Valeria; Evsukova, Arina; Elovenko, Daria; Adushkina, Viktoria; Tzoy, Maria; Dmitrenko, Alexander; Krupnova, Valeria; Manzhaeva, Maria; Agranovich, Ilana; Saranceva, Elena; Iskra, Tatyana; Lykova, Ekaterina; Sokolovski, Sergey; Rafailov, Edik; Kurths, Jürgen

doi:10.1007/978-3-031-42003-0_8

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Mechanisms of Photostimulation of Brain's Waste Disposal System: The Role of Singlet Oxygen

Authors

Semyachkina-Glushkovskaya, Oxana
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Bragin, Denis
External Organizations;

Fedosov, Ivan
External Organizations;

Blokhina, Inna
External Organizations;

Khorovodov, Alexander
External Organizations;

Terskov, Andrey
External Organizations;

Shirokov, Alexander
External Organizations;

Dubrovsky, Alexander
External Organizations;

Vinnik, Valeria
External Organizations;

Evsukova, Arina
External Organizations;

Elovenko, Daria
External Organizations;

Adushkina, Viktoria
External Organizations;

Tzoy, Maria
External Organizations;

Dmitrenko, Alexander
External Organizations;

Krupnova, Valeria
External Organizations;

Manzhaeva, Maria
External Organizations;

Agranovich, Ilana
External Organizations;

Saranceva, Elena
External Organizations;

Iskra, Tatyana
External Organizations;

Lykova, Ekaterina
External Organizations;

Sokolovski, Sergey
External Organizations;

Rafailov, Edik
External Organizations;

/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

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Citation

Semyachkina-Glushkovskaya, O., Bragin, D., Fedosov, I., Blokhina, I., Khorovodov, A., Terskov, A., Shirokov, A., Dubrovsky, A., Vinnik, V., Evsukova, A., Elovenko, D., Adushkina, V., Tzoy, M., Dmitrenko, A., Krupnova, V., Manzhaeva, M., Agranovich, I., Saranceva, E., Iskra, T., Lykova, E., Sokolovski, S., Rafailov, E., Kurths, J. (2023): Mechanisms of Photostimulation of Brain's Waste Disposal System: The Role of Singlet Oxygen. - In: Scholkmann, F., LaManna, J., Wolf, U. (Eds.), Oxygen Transport to Tissue XLIV, Cham : Springer, 45-50.
https://doi.org/10.1007/978-3-031-42003-0_8

Cite as: https://publications.pik-potsdam.de/pubman/item/item_29462

Abstract

There is strong evidence that augmentation of the brain’s waste disposal system via stimulation of the meningeal lymphatics might be a promising therapeutic target for preventing neurological diseases. In our previous studies, we demonstrated activation of the brain’s waste disposal system using transcranial photostimulation (PS) with a laser 1267 nm, which stimulates the direct generation of singlet oxygen in the brain tissues. Here we investigate the mechanisms underlying this phenomenon. Our results clearly demonstrate that PS-mediated stimulation of the brain’s waste disposal system is accompanied by activation of lymphatic contractility associated with subsequent intracellular production of the reactive oxygen species and the nitric oxide underlying lymphatic relaxation. Thus, PS stimulates the brain’s waste disposal system by influencing the mechanisms of regulation of lymphatic pumping.