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  Mechanisms of Photostimulation of Brain's Waste Disposal System: The Role of Singlet Oxygen

Semyachkina-Glushkovskaya, O., Bragin, D., Fedosov, I., Blokhina, I., Khorovodov, A., Terskov, A., Shirokov, A., Dubrovsky, A., Vinnik, V., Evsukova, A., Elovenko, D., Adushkina, V., Tzoy, M., Dmitrenko, A., Krupnova, V., Manzhaeva, M., Agranovich, I., Saranceva, E., Iskra, T., Lykova, E., Sokolovski, S., Rafailov, E., Kurths, J. (2023): Mechanisms of Photostimulation of Brain's Waste Disposal System: The Role of Singlet Oxygen. - In: Scholkmann, F., LaManna, J., Wolf, U. (Eds.), Oxygen Transport to Tissue XLIV, Cham : Springer, 45-50.
https://doi.org/10.1007/978-3-031-42003-0_8

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Item Permalink: https://publications.pik-potsdam.de/pubman/item/item_29462 Version Permalink: https://publications.pik-potsdam.de/pubman/item/item_29462_1
Genre: Book Chapter

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 Creators:
Semyachkina-Glushkovskaya, Oxana1, Author
Bragin, Denis1, Author
Fedosov, Ivan1, Author
Blokhina, Inna1, Author
Khorovodov, Alexander1, Author
Terskov, Andrey1, Author
Shirokov, Alexander1, Author
Dubrovsky, Alexander1, Author
Vinnik, Valeria1, Author
Evsukova, Arina1, Author
Elovenko, Daria1, Author
Adushkina, Viktoria1, Author
Tzoy, Maria1, Author
Dmitrenko, Alexander1, Author
Krupnova, Valeria1, Author
Manzhaeva, Maria1, Author
Agranovich, Ilana1, Author
Saranceva, Elena1, Author
Iskra, Tatyana1, Author
Lykova, Ekaterina1, Author
Sokolovski, Sergey1, AuthorRafailov, Edik1, AuthorKurths, Jürgen2, Author               more..
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Abstract: There is strong evidence that augmentation of the brain’s waste disposal system via stimulation of the meningeal lymphatics might be a promising therapeutic target for preventing neurological diseases. In our previous studies, we demonstrated activation of the brain’s waste disposal system using transcranial photostimulation (PS) with a laser 1267 nm, which stimulates the direct generation of singlet oxygen in the brain tissues. Here we investigate the mechanisms underlying this phenomenon. Our results clearly demonstrate that PS-mediated stimulation of the brain’s waste disposal system is accompanied by activation of lymphatic contractility associated with subsequent intracellular production of the reactive oxygen species and the nitric oxide underlying lymphatic relaxation. Thus, PS stimulates the brain’s waste disposal system by influencing the mechanisms of regulation of lymphatic pumping.

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Language(s): eng - English
 Dates: 2023-10-172023-10-17
 Publication Status: Finally published
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/978-3-031-42003-0_8
MDB-ID: No data to archive
PIKDOMAIN: RD4 - Complexity Science
Organisational keyword: RD4 - Complexity Science
Research topic keyword: Health
Research topic keyword: Nonlinear Dynamics
Model / method: Nonlinear Data Analysis
 Degree: -

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Title: Oxygen Transport to Tissue XLIV
Source Genre: Book
 Creator(s):
Scholkmann, Felix1, Editor
LaManna, Joseph1, Editor
Wolf, Ursula1, Editor
Affiliations:
1 External Organizations, ou_persistent22            
Publ. Info: Cham : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 45 - 50 Identifier: DOI: 10.1007/978-3-031-42003-0
ISBN: 978-3-031-42003-0