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  GB20 Pharmacopuncture As a Potential Method for Brain Drug Delivery via the Perivascular Spaces

Semyachkina-Glushkovskaya, O., Blokhina, I., Navolokin, N., Evsukova, A., Karandin, G., Khorovodov, A., Terskov, A., Fedosov, I., Dubrovsky, A., Tzoy, M., Ageev, V., Agranovich, I., Telnova, V., Tsven, A., Kurths, J. (2022): GB20 Pharmacopuncture As a Potential Method for Brain Drug Delivery via the Perivascular Spaces. - Journal of Acupuncture and Meridian Studies, 15, 1, 43-49.
https://doi.org/10.51507/j.jams.2022.15.1.43

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Semyachkina-Glushkovskaya, Oxana1, Autor
Blokhina, Inna1, Autor
Navolokin, Nikita1, Autor
Evsukova, Arina1, Autor
Karandin, Georgy1, Autor
Khorovodov, Alexander1, Autor
Terskov, Andrey1, Autor
Fedosov, Ivan1, Autor
Dubrovsky, Alexander1, Autor
Tzoy, Maria1, Autor
Ageev, Vasily1, Autor
Agranovich, Ilana1, Autor
Telnova, Valeria1, Autor
Tsven, Anna1, Autor
Kurths, Jürgen2, Autor              
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Zusammenfassung: Background: The development of new methods of drug brain delivery is a crucial step for the effective therapy of the brain diseases. Pharma- and acupuncture are the forms of alternative therapy of the brain pathology, including an increase in the permeability of blood-brain barrier. However, the mechanisms of pharma- and acupuncture-mediated effects on the brain physiology remain not fully understood. Results: This pilot study on healthy mice clearly demonstrates the Evans Blue spreading in the mouse head and in the brain via the perivascular spaces (PVSs) of the trigeminal structure and the cribriform plate after the dye injection into the Feng Chi point (Galbladder 20, GB20). Conclusion: These results suggest that pharmacopuncture at GB20 can be a perspective method for brain drug delivery via PVSs.

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Sprache(n): eng - Englisch
 Datum: 2022-02-282022-02
 Publikationsstatus: Final veröffentlicht
 Seiten: 7
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.51507/j.jams.2022.15.1.43
MDB-ID: No data to archive
PIKDOMAIN: RD4 - Complexity Science
Organisational keyword: RD4 - Complexity Science
Research topic keyword: Health
Research topic keyword: Nonlinear Dynamics
Model / method: Nonlinear Data Analysis
OATYPE: Gold Open Access
 Art des Abschluß: -

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Titel: Journal of Acupuncture and Meridian Studies
Genre der Quelle: Zeitschrift, Scopus, p3, oa
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 15 (1) Artikelnummer: - Start- / Endseite: 43 - 49 Identifikator: CoNE: https://publications.pik-potsdam.de/cone/journals/resource/2093-8152
Publisher: Medical Association of Pharmacopuncture Institute