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Journal Article

GB20 Pharmacopuncture As a Potential Method for Brain Drug Delivery via the Perivascular Spaces

Authors

Semyachkina-Glushkovskaya,  Oxana
External Organizations;

Blokhina,  Inna
External Organizations;

Navolokin,  Nikita
External Organizations;

Evsukova,  Arina
External Organizations;

Karandin,  Georgy
External Organizations;

Khorovodov,  Alexander
External Organizations;

Terskov,  Andrey
External Organizations;

Fedosov,  Ivan
External Organizations;

Dubrovsky,  Alexander
External Organizations;

Tzoy,  Maria
External Organizations;

Ageev,  Vasily
External Organizations;

Agranovich,  Ilana
External Organizations;

Telnova,  Valeria
External Organizations;

Tsven,  Anna
External Organizations;

/persons/resource/Juergen.Kurths

Kurths,  Jürgen
Potsdam Institute for Climate Impact Research;

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Fulltext (public)

27046oa.pdf
(Publisher version), 9MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Semyachkina-Glushkovskaya, O., Blokhina, I., Navolokin, N., Evsukova, A., Karandin, G., Khorovodov, A., Terskov, A., Fedosov, I., Dubrovsky, A., Tzoy, M., Ageev, V., Agranovich, I., Telnova, V., Tsven, A., Kurths, J. (2022): GB20 Pharmacopuncture As a Potential Method for Brain Drug Delivery via the Perivascular Spaces. - Journal of Acupuncture and Meridian Studies, 15, 1, 43-49.
https://doi.org/10.51507/j.jams.2022.15.1.43


Cite as: https://publications.pik-potsdam.de/pubman/item/item_27046
Abstract
Background: The development of new methods of drug brain delivery is a crucial step for the effective therapy of the brain diseases. Pharma- and acupuncture are the forms of alternative therapy of the brain pathology, including an increase in the permeability of blood-brain barrier. However, the mechanisms of pharma- and acupuncture-mediated effects on the brain physiology remain not fully understood. Results: This pilot study on healthy mice clearly demonstrates the Evans Blue spreading in the mouse head and in the brain via the perivascular spaces (PVSs) of the trigeminal structure and the cribriform plate after the dye injection into the Feng Chi point (Galbladder 20, GB20). Conclusion: These results suggest that pharmacopuncture at GB20 can be a perspective method for brain drug delivery via PVSs.