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  Lymphatic Clearance from the Blood after Subarachnoid Hemorrhages

Semyachkina-Glushkovskaya, O., Abdurashitov, A., Dubrovsky, A., Shirokov, A., Navolokin, N., Klimova, M., Duarte Torres, E., Khorovodov, A., Mamedova, A., Shareef, A. E., Terskov, A., Saranceva, E., Iskra, T., Kurths, J. (2019): Lymphatic Clearance from the Blood after Subarachnoid Hemorrhages. - In: Luo, Q., Ding, J., Fu, L. (Eds.), Neural Imaging and Sensing 2019, (Proceedings of SPIE ; 10865), Bellingham : Society of Photo-Optical Instrumentation Engineers (SPIE), 108650T.
https://doi.org/10.1117/12.2509065

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 Creators:
Semyachkina-Glushkovskaya, O.1, Author
Abdurashitov, A.1, Author
Dubrovsky, A.1, Author
Shirokov, A.1, Author
Navolokin, N.1, Author
Klimova, M.1, Author
Duarte Torres, E.1, Author
Khorovodov, A.1, Author
Mamedova, A.1, Author
Shareef, A. E.1, Author
Terskov, A.1, Author
Saranceva, E.1, Author
Iskra, T.1, Author
Kurths, Jürgen2, Author              
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Abstract: Here we present preliminary experimental data suggesting about involvement of the meningeal and cervical lymphatics in neurorehabilitation. Using model of hemorrhagic stroke, immunohistochemical analysis and atomic absorption spectroscopy, we clearly demonstrate the lymphatic clearance from the blood after stroke via the meningeal lymphatic vessels with further accumulation of hemosiderin and iron (products of disaggregated hemoglobin) in the deep cervical node (dcLN). The optical coherent tomography (OCT) was used for in vivo monitoring of accumulation of gold nanorods (92 nm in diameter) in the dcLN after their injection into the cisterna magna with the aim of mimicking of the brain clearance from of blood. The both ex vivo and in vivo data show the lymphatic clearance from subjects (the blood/GNRs) injected into the subarachnoid space that might be an important mechanism of neurorehabilitation after the intracranial hemorrhages.

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 Dates: 2019
 Publication Status: Finally published
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1117/12.2509065
PIKDOMAIN: RD4 - Complexity Science
eDoc: 8929
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Title: Neural Imaging and Sensing 2019
Source Genre: Book
 Creator(s):
Luo, Q.1, Editor
Ding, J.1, Editor
Fu, L.1, Editor
Affiliations:
1 External Organizations, ou_persistent22            
Publ. Info: Bellingham : Society of Photo-Optical Instrumentation Engineers (SPIE)
Pages: - Volume / Issue: - Sequence Number: 108650T Start / End Page: - Identifier: -

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Title: Proceedings of SPIE
Source Genre: Series
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Pages: - Volume / Issue: 10865 Sequence Number: - Start / End Page: - Identifier: -