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  Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy

Semyachkina-Glushkovskaya, O., Fedosov, I., Shirokov, A., Vodovozova, E., Alekseeva, A., Khorovodov, A., Blokhina, I., Terskov, A., Mamedova, A., Klimova, M., Dubrovsky, A., Ageev, V., Agranovich, I., Vinnik, V., Tsven, A., Sokolovski, S., Rafailov, E., Penzel, T., Kurths, J. (2021): Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy. - Nanophotonics, 10, 12, 3215-3227.
https://doi.org/10.1515/nanoph-2021-0212

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Semyachkina-Glushkovskaya, Oxana1, Autor
Fedosov, Ivan1, Autor
Shirokov, Alexander1, Autor
Vodovozova, Elena1, Autor
Alekseeva, Anna1, Autor
Khorovodov, Alexandr1, Autor
Blokhina, Inna1, Autor
Terskov, Andrey1, Autor
Mamedova, Aysel1, Autor
Klimova, Maria1, Autor
Dubrovsky, Alexander1, Autor
Ageev, Vasily1, Autor
Agranovich, Ilana1, Autor
Vinnik, Valeria1, Autor
Tsven, Anna1, Autor
Sokolovski, Sergey1, Autor
Rafailov, Edik1, Autor
Penzel, Thomas1, Autor
Kurths, Jürgen2, Autor              
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Zusammenfassung: The blood-brain barrier (BBB) has a significant contribution to the protection of the central nervous system (CNS). However, it also limits the brain drug delivery and thereby complicates the treatment of CNS diseases. The development of safe methods for an effective delivery of medications and nanocarriers to the brain can be a revolutionary step in the overcoming this limitation. Here, we report the unique properties of the lymphatic system to deliver tracers and liposomes to the brain meninges, brain tissues, and glioma in rats. Using a quantum-dot-based 1267 nm laser (for photosensitizer-free generation of singlet oxygen), we clearly demonstrate photostimulation of lymphatic delivery of liposomes to glioma as well as lymphatic clearance of liposomes from the brain. These pilot findings open promising perspectives for photomodulation of lymphatic delivery of drugs and nanocarriers to the brain pathology bypassing the BBB. The lymphatic “smart” delivery of liposomes with antitumor drugs in the new brain tumor branches might be a breakthrough strategy for the therapy of gliomas.

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 Datum: 2021-07-092021-07-09
 Publikationsstatus: Final veröffentlicht
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1515/nanoph-2021-0212
MDB-ID: No data to archive
PIKDOMAIN: RD4 - Complexity Science
Organisational keyword: RD4 - Complexity Science
Research topic keyword: Health
Model / method: Nonlinear Data Analysis
OATYPE: Gold Open Access
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Titel: Nanophotonics
Genre der Quelle: Zeitschrift, SCI, Scopus, oa
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Seiten: - Band / Heft: 10 (12) Artikelnummer: - Start- / Endseite: 3215 - 3227 Identifikator: CoNE: https://publications.pik-potsdam.de/cone/journals/resource/nanophotonics
Publisher: De Gruyter