Photomodulation of lymphatic delivery of liposomes to the brain bypassing the 
blood-brain barrier: new perspectives for glioma therapy

Semyachkina-Glushkovskaya, Oxana; Fedosov, Ivan; Shirokov, Alexander; Vodovozova, Elena; Alekseeva, Anna; Khorovodov, Alexandr; Blokhina, Inna; Terskov, Andrey; Mamedova, Aysel; Klimova, Maria; Dubrovsky, Alexander; Ageev, Vasily; Agranovich, Ilana; Vinnik, Valeria; Tsven, Anna; Sokolovski, Sergey; Rafailov, Edik; Penzel, Thomas; Kurths, Jürgen

doi:10.1515/nanoph-2021-0212

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学術論文

Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy

Authors

Semyachkina-Glushkovskaya, Oxana
External Organizations;

Fedosov, Ivan
External Organizations;

Shirokov, Alexander
External Organizations;

Vodovozova, Elena
External Organizations;

Alekseeva, Anna
External Organizations;

Khorovodov, Alexandr
External Organizations;

Blokhina, Inna
External Organizations;

Terskov, Andrey
External Organizations;

Mamedova, Aysel
External Organizations;

Klimova, Maria
External Organizations;

Dubrovsky, Alexander
External Organizations;

Ageev, Vasily
External Organizations;

Agranovich, Ilana
External Organizations;

Vinnik, Valeria
External Organizations;

Tsven, Anna
External Organizations;

Sokolovski, Sergey
External Organizations;

Rafailov, Edik
External Organizations;

Penzel, Thomas
External Organizations;

/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

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フルテキスト (公開)

semyachkina_2021_10.1515_nanoph-2021-0212.pdf
(出版社版), 4MB

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引用

Semyachkina-Glushkovskaya, O., Fedosov, I., Shirokov, A., Vodovozova, E., Alekseeva, A., Khorovodov, A., Blokhina, I., Terskov, A., Mamedova, A., Klimova, M., Dubrovsky, A., Ageev, V., Agranovich, I., Vinnik, V., Tsven, A., Sokolovski, S., Rafailov, E., Penzel, T., & Kurths, J. (2021). Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy. Nanophotonics, 10(12), 3215-3227. doi:10.1515/nanoph-2021-0212.

引用: https://publications.pik-potsdam.de/pubman/item/item_26318

要旨

The blood-brain barrier (BBB) has a significant contribution to the protection of the central nervous system (CNS). However, it also limits the brain drug delivery and thereby complicates the treatment of CNS diseases. The development of safe methods for an effective delivery of medications and nanocarriers to the brain can be a revolutionary step in the overcoming this limitation. Here, we report the unique properties of the lymphatic system to deliver tracers and liposomes to the brain meninges, brain tissues, and glioma in rats. Using a quantum-dot-based 1267 nm laser (for photosensitizer-free generation of singlet oxygen), we clearly demonstrate photostimulation of lymphatic delivery of liposomes to glioma as well as lymphatic clearance of liposomes from the brain. These pilot findings open promising perspectives for photomodulation of lymphatic delivery of drugs and nanocarriers to the brain pathology bypassing the BBB. The lymphatic “smart” delivery of liposomes with antitumor drugs in the new brain tumor branches might be a breakthrough strategy for the therapy of gliomas.