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  Transcranial Photobiomodulation of Clearance of Beta-Amyloid from the Mouse Brain: Effects on the Meningeal Lymphatic Drainage and Blood Oxygen Saturation of the Brain

Semyachkina-Glushkovskaya, O., Klimova, M., Iskra, T., Bragin, D., Abdurashitov, A., Dubrovsky, A., Khorovodov, A., Terskov, A., Blokhina, I., Lezhnev, N., Vinnik, V., Agranovich, I., Mamedova, A., Shirokov, A., Navolokin, N., Khlebsov, B., Tuchin, V., Kurths, J. (2021): Transcranial Photobiomodulation of Clearance of Beta-Amyloid from the Mouse Brain: Effects on the Meningeal Lymphatic Drainage and Blood Oxygen Saturation of the Brain. - In: Nemoto, E. M., Harrison, E. M., Pias, S. C., Bragin, D. E., Harrison, D. K., LaManna, J. C. (Eds.), Oxygen Transport to Tissue XLII, (Advances in Experimental Medicine and Biology ; 1269), Cham : Springer, 57-61.
https://doi.org/10.1007/978-3-030-48238-1_9

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Item Permalink: https://publications.pik-potsdam.de/pubman/item/item_27056 Version Permalink: https://publications.pik-potsdam.de/pubman/item/item_27056_1
Genre: Book Chapter

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 Creators:
Semyachkina-Glushkovskaya, Oxana1, Author
Klimova, M.1, Author
Iskra, T.1, Author
Bragin, D.1, Author
Abdurashitov, A.1, Author
Dubrovsky, A.1, Author
Khorovodov, A.1, Author
Terskov, A.1, Author
Blokhina, I.1, Author
Lezhnev, N.1, Author
Vinnik, V.1, Author
Agranovich, I.1, Author
Mamedova, A.1, Author
Shirokov, A.1, Author
Navolokin, N.1, Author
Khlebsov, B.1, Author
Tuchin, V.1, Author
Kurths, Jürgen2, Author              
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Abstract: Here, we demonstrate the therapeutic effects of transcranial photobiomodulation (tPBM, 1267 nm, 32 J/cm2, a 9-day course) in mice with the injected model of Alzheimer’s disease (AD) associated with accumulation of beta-amyloid (Aβ) in the brain resulting in neurocognitive deficit vs. the control group (CG) (the neurological severity score (NNS), AD 3.67 ± 0.58 vs. CG 1.00 ± 0.26%, p < 0.05) and mild cerebral hypoxia (AD 72 ± 6% vs. CG 97 ± 2%, p < 0.001). The course of tPBM improved neurocognitive status of mice with AD (NNS, AD 2.03 ± 0.14 vs. CG 1.00 ± 0.26, vs. 2.03 ± 0.14, p < 0.05) due to stimulation of clearance of Aβ from the brain via the meningeal lymphatic vessels (the immunohistochemical and confocal data) and an increase in blood oxygen saturation of the brain tissues (the pulse oximetry data) till 85 ± 2%, p < 0.05. These results open breakthrough strategies for non-pharmacological therapy of AD and clearly demonstrate that tPBM might be a promising therapeutic target for preventing or delaying AD based on stimulation of oxygenation of the brain tissues and activation of clearance of toxic molecules via the cerebral lymphatics.

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Language(s): eng - English
 Dates: 2021-05-092021
 Publication Status: Finally published
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/978-3-030-48238-1_9
MDB-ID: No data to archive
PIKDOMAIN: RD4 - Complexity Science
Organisational keyword: RD4 - Complexity Science
Research topic keyword: Health
Model / method: Nonlinear Data Analysis
 Degree: -

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Title: Oxygen Transport to Tissue XLII
Source Genre: Book
 Creator(s):
Nemoto, Edwin M.1, Editor
Harrison, Eileen M.1, Editor
Pias, Sally C.1, Editor
Bragin, Denis E.1, Editor
Harrison, David K.1, Editor
LaManna, Joseph C.1, Editor
Affiliations:
1 External Organizations, ou_persistent22            
Publ. Info: Cham : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 57 - 61 Identifier: ISBN: 978-3-030-48236-7
ISBN: 978-3-030-48238-1

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Title: Advances in Experimental Medicine and Biology
Source Genre: Series
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Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 1269 Sequence Number: - Start / End Page: - Identifier: -