Transcranial Photobiomodulation of Clearance of Beta-Amyloid from the Mouse 
Brain: Effects on the Meningeal Lymphatic Drainage and Blood Oxygen Saturation 
of the Brain

Semyachkina-Glushkovskaya, Oxana; Klimova, M.; Iskra, T.; Bragin, D.; Abdurashitov, A.; Dubrovsky, A.; Khorovodov, A.; Terskov, A.; Blokhina, I.; Lezhnev, N.; Vinnik, V.; Agranovich, I.; Mamedova, A.; Shirokov, A.; Navolokin, N.; Khlebsov, B.; Tuchin, V.; Kurths, Jürgen

doi:10.1007/978-3-030-48238-1_9

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Transcranial Photobiomodulation of Clearance of Beta-Amyloid from the Mouse Brain: Effects on the Meningeal Lymphatic Drainage and Blood Oxygen Saturation of the Brain

Authors

Semyachkina-Glushkovskaya, Oxana
External Organizations;

Klimova, M.
External Organizations;

Iskra, T.
External Organizations;

Bragin, D.
External Organizations;

Abdurashitov, A.
External Organizations;

Dubrovsky, A.
External Organizations;

Khorovodov, A.
External Organizations;

Terskov, A.
External Organizations;

Blokhina, I.
External Organizations;

Lezhnev, N.
External Organizations;

Vinnik, V.
External Organizations;

Agranovich, I.
External Organizations;

Mamedova, A.
External Organizations;

Shirokov, A.
External Organizations;

Navolokin, N.
External Organizations;

Khlebsov, B.
External Organizations;

Tuchin, V.
External Organizations;

/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

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引用

Semyachkina-Glushkovskaya, O., Klimova, M., Iskra, T., Bragin, D., Abdurashitov, A., Dubrovsky, A., Khorovodov, A., Terskov, A., Blokhina, I., Lezhnev, N., Vinnik, V., Agranovich, I., Mamedova, A., Shirokov, A., Navolokin, N., Khlebsov, B., Tuchin, V., & Kurths, J. (2021). Transcranial Photobiomodulation of Clearance of Beta-Amyloid from the Mouse Brain: Effects on the Meningeal Lymphatic Drainage and Blood Oxygen Saturation of the Brain. In E. M., Nemoto, E. M., Harrison, S. C., Pias, D. E., Bragin, D. K., Harrison, & J. C., LaManna (Eds.), Oxygen Transport to Tissue XLII (pp. 57-61). Cham: Springer. doi:10.1007/978-3-030-48238-1_9.

引用: https://publications.pik-potsdam.de/pubman/item/item_27056

要旨

Here, we demonstrate the therapeutic effects of transcranial photobiomodulation (tPBM, 1267 nm, 32 J/cm2, a 9-day course) in mice with the injected model of Alzheimer’s disease (AD) associated with accumulation of beta-amyloid (Aβ) in the brain resulting in neurocognitive deficit vs. the control group (CG) (the neurological severity score (NNS), AD 3.67 ± 0.58 vs. CG 1.00 ± 0.26%, p < 0.05) and mild cerebral hypoxia (AD 72 ± 6% vs. CG 97 ± 2%, p < 0.001). The course of tPBM improved neurocognitive status of mice with AD (NNS, AD 2.03 ± 0.14 vs. CG 1.00 ± 0.26, vs. 2.03 ± 0.14, p < 0.05) due to stimulation of clearance of Aβ from the brain via the meningeal lymphatic vessels (the immunohistochemical and confocal data) and an increase in blood oxygen saturation of the brain tissues (the pulse oximetry data) till 85 ± 2%, p < 0.05. These results open breakthrough strategies for non-pharmacological therapy of AD and clearly demonstrate that tPBM might be a promising therapeutic target for preventing or delaying AD based on stimulation of oxygenation of the brain tissues and activation of clearance of toxic molecules via the cerebral lymphatics.