English
 
Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System

Semyachkina-Glushkovskaya, O., Shirokov, A., Blokhina, I., Telnova, V., Vodovozova, E., Alekseeva, A., Boldyrev, I., Fedosov, I., Dubrovsky, A., Khorovodov, A., Terskov, A., Evsukova, A., Elovenko, D., Adushkina, V., Tzoy, M., Agranovich, I., Kurths, J., Rafailov, E. (2023): Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System. - Pharmaceutics, 15, 1, 36.
https://doi.org/10.3390/pharmaceutics15010036

Item is

Files

show Files
hide Files
:
semyachkina_2023_pharmaceutics-15-00036-v3.pdf (Publisher version), 3MB
Name:
semyachkina_2023_pharmaceutics-15-00036-v3.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Semyachkina-Glushkovskaya, Oxana1, Author
Shirokov, Alexander1, Author
Blokhina, Inna1, Author
Telnova, Valeria1, Author
Vodovozova, Elena1, Author
Alekseeva, Anna1, Author
Boldyrev, Ivan1, Author
Fedosov, Ivan1, Author
Dubrovsky, Alexander1, Author
Khorovodov, Alexandr1, Author
Terskov, Andrey1, Author
Evsukova, Arina1, Author
Elovenko, Daria1, Author
Adushkina, Viktoria1, Author
Tzoy, Maria1, Author
Agranovich, Ilana1, Author
Kurths, Jürgen2, Author              
Rafailov, Edik1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

Content

show
hide
Free keywords: -
 Abstract: The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB. However, in most cases, this method is not sufficient to achieve a therapeutic effect due to brain drug delivery in a short distance. Therefore, it is necessary to develop technologies to overcome the obstacles facing nose-to-brain delivery of promising pharmaceuticals. In this study, we clearly demonstrate intranasal delivery of liposomes to the mouse brain reaching glioblastoma (GBM). In the experiments with ablation of the meningeal lymphatic network, we report an important role of meningeal pathway for intranasal delivery of liposomes to the brain. Our data revealed that GBM is characterized by a dramatic reduction of intranasal delivery of liposomes to the brain that was significantly improved by near-infrared (1267 nm) photostimulation of the lymphatic vessels in the area of the cribriform plate and the meninges. These results open new perspectives for non-invasive improvement of efficiency of intranasal delivery of cancer drugs to the brain tissues using nanocarriers and near-infrared laser-based therapeutic devices, which are commercially available and widely used in clinical practice.

Details

show
hide
Language(s): eng - English
 Dates: 2022-12-222023-01
 Publication Status: Finally published
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3390/pharmaceutics15010036
MDB-ID: No data to archive
PIKDOMAIN: RD4 - Complexity Science
Organisational keyword: RD4 - Complexity Science
Research topic keyword: Complex Networks
Research topic keyword: Health
Research topic keyword: Nonlinear Dynamics
Model / method: Machine Learning
OATYPE: Gold Open Access
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Pharmaceutics
Source Genre: Journal, SCI, Scopus, oa
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 15 (1) Sequence Number: 36 Start / End Page: - Identifier: CoNE: https://publications.pik-potsdam.de/cone/journals/resource/1999-4923