Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the 
Lymphatic System

Semyachkina-Glushkovskaya, Oxana; Shirokov, Alexander; Blokhina, Inna; Telnova, Valeria; Vodovozova, Elena; Alekseeva, Anna; Boldyrev, Ivan; Fedosov, Ivan; Dubrovsky, Alexander; Khorovodov, Alexandr; Terskov, Andrey; Evsukova, Arina; Elovenko, Daria; Adushkina, Viktoria; Tzoy, Maria; Agranovich, Ilana; Kurths, Jürgen; Rafailov, Edik

doi:10.3390/pharmaceutics15010036

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Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System

Urheber*innen

Semyachkina-Glushkovskaya, Oxana
External Organizations;

Shirokov, Alexander
External Organizations;

Blokhina, Inna
External Organizations;

Telnova, Valeria
External Organizations;

Vodovozova, Elena
External Organizations;

Alekseeva, Anna
External Organizations;

Boldyrev, Ivan
External Organizations;

Fedosov, Ivan
External Organizations;

Dubrovsky, Alexander
External Organizations;

Khorovodov, Alexandr
External Organizations;

Terskov, Andrey
External Organizations;

Evsukova, Arina
External Organizations;

Elovenko, Daria
External Organizations;

Adushkina, Viktoria
External Organizations;

Tzoy, Maria
External Organizations;

Agranovich, Ilana
External Organizations;

/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

Rafailov, Edik
External Organizations;

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Zitation

Semyachkina-Glushkovskaya, O., Shirokov, A., Blokhina, I., Telnova, V., Vodovozova, E., Alekseeva, A., Boldyrev, I., Fedosov, I., Dubrovsky, A., Khorovodov, A., Terskov, A., Evsukova, A., Elovenko, D., Adushkina, V., Tzoy, M., Agranovich, I., Kurths, J., Rafailov, E. (2023): Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System. - Pharmaceutics, 15, 1, 36.
https://doi.org/10.3390/pharmaceutics15010036

Zitierlink: https://publications.pik-potsdam.de/pubman/item/item_28319

Zusammenfassung

The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB. However, in most cases, this method is not sufficient to achieve a therapeutic effect due to brain drug delivery in a short distance. Therefore, it is necessary to develop technologies to overcome the obstacles facing nose-to-brain delivery of promising pharmaceuticals. In this study, we clearly demonstrate intranasal delivery of liposomes to the mouse brain reaching glioblastoma (GBM). In the experiments with ablation of the meningeal lymphatic network, we report an important role of meningeal pathway for intranasal delivery of liposomes to the brain. Our data revealed that GBM is characterized by a dramatic reduction of intranasal delivery of liposomes to the brain that was significantly improved by near-infrared (1267 nm) photostimulation of the lymphatic vessels in the area of the cribriform plate and the meninges. These results open new perspectives for non-invasive improvement of efficiency of intranasal delivery of cancer drugs to the brain tissues using nanocarriers and near-infrared laser-based therapeutic devices, which are commercially available and widely used in clinical practice.