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  Mechanisms of Photostimulation of Brain's Waste Disposal System: The Role of Singlet Oxygen

Semyachkina-Glushkovskaya, O., Bragin, D., Fedosov, I., Blokhina, I., Khorovodov, A., Terskov, A., Shirokov, A., Dubrovsky, A., Vinnik, V., Evsukova, A., Elovenko, D., Adushkina, V., Tzoy, M., Dmitrenko, A., Krupnova, V., Manzhaeva, M., Agranovich, I., Saranceva, E., Iskra, T., Lykova, E., Sokolovski, S., Rafailov, E., Kurths, J. (2023): Mechanisms of Photostimulation of Brain's Waste Disposal System: The Role of Singlet Oxygen. - In: Scholkmann, F., LaManna, J., Wolf, U. (Eds.), Oxygen Transport to Tissue XLIV, Cham : Springer, 45-50.
https://doi.org/10.1007/978-3-031-42003-0_8

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 Urheber:
Semyachkina-Glushkovskaya, Oxana1, Autor
Bragin, Denis1, Autor
Fedosov, Ivan1, Autor
Blokhina, Inna1, Autor
Khorovodov, Alexander1, Autor
Terskov, Andrey1, Autor
Shirokov, Alexander1, Autor
Dubrovsky, Alexander1, Autor
Vinnik, Valeria1, Autor
Evsukova, Arina1, Autor
Elovenko, Daria1, Autor
Adushkina, Viktoria1, Autor
Tzoy, Maria1, Autor
Dmitrenko, Alexander1, Autor
Krupnova, Valeria1, Autor
Manzhaeva, Maria1, Autor
Agranovich, Ilana1, Autor
Saranceva, Elena1, Autor
Iskra, Tatyana1, Autor
Lykova, Ekaterina1, Autor
Sokolovski, Sergey1, AutorRafailov, Edik1, AutorKurths, Jürgen2, Autor               mehr..
Affiliations:
1External Organizations, ou_persistent22              
2Potsdam Institute for Climate Impact Research, ou_persistent13              

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 Zusammenfassung: There is strong evidence that augmentation of the brain’s waste disposal system via stimulation of the meningeal lymphatics might be a promising therapeutic target for preventing neurological diseases. In our previous studies, we demonstrated activation of the brain’s waste disposal system using transcranial photostimulation (PS) with a laser 1267 nm, which stimulates the direct generation of singlet oxygen in the brain tissues. Here we investigate the mechanisms underlying this phenomenon. Our results clearly demonstrate that PS-mediated stimulation of the brain’s waste disposal system is accompanied by activation of lymphatic contractility associated with subsequent intracellular production of the reactive oxygen species and the nitric oxide underlying lymphatic relaxation. Thus, PS stimulates the brain’s waste disposal system by influencing the mechanisms of regulation of lymphatic pumping.

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Sprache(n): eng - Englisch
 Datum: 2023-10-172023-10-17
 Publikationsstatus: Final veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1007/978-3-031-42003-0_8
MDB-ID: No data to archive
PIKDOMAIN: RD4 - Complexity Science
Organisational keyword: RD4 - Complexity Science
Research topic keyword: Health
Research topic keyword: Nonlinear Dynamics
Model / method: Nonlinear Data Analysis
 Art des Abschluß: -

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Titel: Oxygen Transport to Tissue XLIV
Genre der Quelle: Buch
 Urheber:
Scholkmann, Felix1, Herausgeber
LaManna, Joseph1, Herausgeber
Wolf, Ursula1, Herausgeber
Affiliations:
1 External Organizations, ou_persistent22            
Ort, Verlag, Ausgabe: Cham : Springer
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: 45 - 50 Identifikator: DOI: 10.1007/978-3-031-42003-0
ISBN: 978-3-031-42003-0