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Journal Article

Music improves the therapeutic effects of bevacizumab in rats with glioblastoma: Modulation of drug distribution to the brain

Authors

Semyachkina-Glushkovskaya,  Oxana
External Organizations;

Diduk,  Sergey
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Anna,  Eroshova
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Elina,  Dosadina
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Artem,  Kruglov
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Khorovodov,  Alexander
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Shirokov,  Alexander
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Fedosov,  Ivan
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Dubrovsky,  Alexander
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Blokhina,  Inna
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Terskov,  Andrey
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Navolokin,  Nikita
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Evsukova,  Arina
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Elovenko,  Daria
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Adushkina,  Viktoria
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/persons/resource/Juergen.Kurths

Kurths,  Jürgen
Potsdam Institute for Climate Impact Research;

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Fulltext (public)

semyachkina_2022_fonc-12-1010188.pdf
(Publisher version), 6MB

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Citation

Semyachkina-Glushkovskaya, O., Diduk, S., Anna, E., Elina, D., Artem, K., Khorovodov, A., Shirokov, A., Fedosov, I., Dubrovsky, A., Blokhina, I., Terskov, A., Navolokin, N., Evsukova, A., Elovenko, D., Adushkina, V., Kurths, J. (2022): Music improves the therapeutic effects of bevacizumab in rats with glioblastoma: Modulation of drug distribution to the brain. - Frontiers in Oncology, 12, 1010188.
https://doi.org/10.3389/fonc.2022.1010188


Cite as: https://publications.pik-potsdam.de/pubman/item/item_27964
Abstract
The development of new methods for modulation of drug distribution across to the brain is a crucial step in the effective therapies for glioblastoma (GBM). In our previous work, we discovered the phenomenon of music-induced opening of the blood-brain barrier (OBBB) in healthy rodents. In this pilot study on rats, we clearly demonstrate that music-induced BBB opening improves the therapeutic effects of bevacizumab (BZM) in rats with GBM via increasing BZM distribution to the brain along the cerebral vessels.