Music improves the therapeutic effects of bevacizumab in rats with 
glioblastoma: Modulation of drug distribution to the brain

Semyachkina-Glushkovskaya, Oxana; Diduk, Sergey; Anna, Eroshova; Elina, Dosadina; Artem, Kruglov; Khorovodov, Alexander; Shirokov, Alexander; Fedosov, Ivan; Dubrovsky, Alexander; Blokhina, Inna; Terskov, Andrey; Navolokin, Nikita; Evsukova, Arina; Elovenko, Daria; Adushkina, Viktoria; Kurths, Jürgen

doi:10.3389/fonc.2022.1010188

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Music improves the therapeutic effects of bevacizumab in rats with glioblastoma: Modulation of drug distribution to the brain

Urheber*innen

Semyachkina-Glushkovskaya, Oxana
External Organizations;

Diduk, Sergey
External Organizations;

Anna, Eroshova
External Organizations;

Elina, Dosadina
External Organizations;

Artem, Kruglov
External Organizations;

Khorovodov, Alexander
External Organizations;

Shirokov, Alexander
External Organizations;

Fedosov, Ivan
External Organizations;

Dubrovsky, Alexander
External Organizations;

Blokhina, Inna
External Organizations;

Terskov, Andrey
External Organizations;

Navolokin, Nikita
External Organizations;

Evsukova, Arina
External Organizations;

Elovenko, Daria
External Organizations;

Adushkina, Viktoria
External Organizations;

/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

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semyachkina_2022_fonc-12-1010188.pdf
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Zitation

Semyachkina-Glushkovskaya, O., Diduk, S., Anna, E., Elina, D., Artem, K., Khorovodov, A., Shirokov, A., Fedosov, I., Dubrovsky, A., Blokhina, I., Terskov, A., Navolokin, N., Evsukova, A., Elovenko, D., Adushkina, V., Kurths, J. (2022): Music improves the therapeutic effects of bevacizumab in rats with glioblastoma: Modulation of drug distribution to the brain. - Frontiers in Oncology, 12, 1010188.
https://doi.org/10.3389/fonc.2022.1010188

Zitierlink: https://publications.pik-potsdam.de/pubman/item/item_27964

Zusammenfassung

The development of new methods for modulation of drug distribution across to the brain is a crucial step in the effective therapies for glioblastoma (GBM). In our previous work, we discovered the phenomenon of music-induced opening of the blood-brain barrier (OBBB) in healthy rodents. In this pilot study on rats, we clearly demonstrate that music-induced BBB opening improves the therapeutic effects of bevacizumab (BZM) in rats with GBM via increasing BZM distribution to the brain along the cerebral vessels.