Novel Promising Stroke Therapy: New Pharmacological and Laser Stimulation of 
Brain Clearance

Semyachkina-Glushkovskaya, O.; Klimova, M.; Duarte Torres, E.; Khorovodov, A.; Terskov, A.; Mamedova, A.; Shareef, A. E.; Saranceva, E.; Iskra, T.; Pavlov, A.; Kurths, Jürgen

doi:10.1117/12.2508259

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Novel Promising Stroke Therapy: New Pharmacological and Laser Stimulation of Brain Clearance

Authors

Semyachkina-Glushkovskaya, O.
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Klimova, M.
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Duarte Torres, E.
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Khorovodov, A.
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Terskov, A.
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Mamedova, A.
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Shareef, A. E.
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Saranceva, E.
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Iskra, T.
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Pavlov, A.
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/persons/resource/Juergen.Kurths

Kurths, Jürgen
Potsdam Institute for Climate Impact Research;

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Citation

Semyachkina-Glushkovskaya, O., Klimova, M., Duarte Torres, E., Khorovodov, A., Terskov, A., Mamedova, A., Shareef, A. E., Saranceva, E., Iskra, T., Pavlov, A., Kurths, J. (2019): Novel Promising Stroke Therapy: New Pharmacological and Laser Stimulation of Brain Clearance. - In: Chen, W. R. (Ed.), Biophotonics and Immune Responses XIV, (Proceedings of SPIE ; 10879), Bellingham : Society of Photo-Optical Instrumentation Engineers (SPIE), 108790C.
https://doi.org/10.1117/12.2508259

Cite as: https://publications.pik-potsdam.de/pubman/item/item_23860

Abstract

Stroke and traumatic brain injury are often associated with formation of brain edema, which is a potentially fatal pathological state provoking extensive accumulation of fluid in the brain tissues resulting in elevation of intracranial pressure and leading to impaired nerve function. There is only symptomatic anti-edema therapy is currently available. Therefore, the development of novel strategies to remove edema fluid is required. The brain edema is classified as vasogenic or cytotoxic edema, which associated with excess accumulation of fluid (edema) around capillaries resulting from disruption of the blood-brain barrier (BBB) or intracellular spaces (cell swelling) of the brain, respectively. In this brief review, we discuss possible mechanisms underlying brain edema formation and new strategies in development of novel of anti-edema drugs.